Items for "guanine nucleotide exchange factor"

Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway

Smurf1, a member of HECT-type E3 ubiquitin ligases, regulates cell polarity and protrusive activity by inducing ubiquitination and subsequent proteasomal degradation of the small GTPase RhoA...

Keywords: C2 domain, E3 ubiquitin ligase, guanine nucleotide exchange factor, HECT domain, PH domain, Rho signaling pathway