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Items for "GTPase"

Monitoring the real-time kinetics of the hydrolysis reaction of guanine nucleotide-binding proteins

The conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and inorganic phosphate (P_i) by guanine nucleotide-binding proteins (GNBPs) is a fundamental enzyme reaction in living cells that acts as an important timer in a variety of biological processes...

Keywords: fluorescence reporter, GTPase, GTPase-activating protein, GTP hydrolysis, guanine nucleotide-binding protein, rhodamine, Spectroscopy

11/2005 | Biological Chemistry, Walter de Gruyter

Asef is a Cdc42-specific guanine nucleotide exchange factor

Asef is a member of the Dbl-family of guanine nucleotide exchange factors (GEFs) with a proposed specificity for the small GTPase Rac1...

Keywords: APC, ASEF, Cdc42, exchange factor, GEF, GTPase, Rac, Rho

01/2007 | Biological Chemistry, Walter de Gruyter

p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho

The Rho family of small GTPases plays a central role in intracellular signal transduction, particularly in reorganization of the actin cytoskeleton...

Keywords: GTPase, p115-RhoGEF, p190-RhoGAP, PDZ-RhoGEF, Rac, Rho, Tiam1

03/2006 | Biological Chemistry, Walter de Gruyter

Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGAP interaction

Down-regulation of Ras signalling is mediated by specific GTPase-activating proteins (GAPs), which stimulate the very slow GTPase reaction of Ras by 10⁵-fold...

Keywords: aluminium fluoride, beryllium fluoride, GTPase, GTPase-activating protein, neurofibromin, oncogene, Ras, transition state