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Items for "growth factor"

Anabolic effects of acellular bone marrow,platelet rich plasma, and serum on equinesuspensory ligament fibroblasts in vitro

The purpose of this study was to investigate the responseof suspensory ligament fibroblasts (SLF) to invitro stimulation using acellular bone marrow (ABM),platelet rich plasma (in vitro PRP), and serum as potentialtreatment modalities for suspensory desmitis.Blood, bone marrow, and suspensory ligaments werecollected from five horses...

Keywords: Bone marrow aspirate, platelet rich plasma, serum, growth factor, suspensory desmitis.

00/0000 | Veterinary and Comparative Orthopaedics and Traumatology, Schattauer
Quantification of vascular endothelial growth factor, interleukin-8, and basic fibroblast growth factor in plasma of cancer patients and healthy volunteers – comparison of ELISA and microsphere-based multiplexed immunoassay

Background: Vascular endothelial growth factor (VEGF), interleukin-8 (IL-8) and basic fibroblast growth factor (basic FGF) are angiogenic growth factors which may be useful as biomarkers in drug development, where they could give early information on the antiangiogenic activity of novel anticancer compounds.

Methods: We compared two commercially available assays, enzyme linked immunosorbent assay (ELISA) and a multiplexed bead-based immunoassay (xMAP), for the quantification of these factors in plasma samples from more than 100 cancer patients and healthy individuals.

Results: For VEGF and IL-8, but not for basic FGF, xMAP was more sensitive than the respective ELISA...

Keywords: Angiogenesis, biomarker, Cancer, growth factor, immunoassay

09/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter