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Items for "glycosylation"

Biochemical and pharmacological characterization of the human bradykinin subtype 2 receptor produced in mammalian cells using the Semliki Forest virus system

Bradykinin, a vasoactive peptide, plays a crucial role in many cardiovascular processes via activation of the bradykinin subtype 2 receptor (B₂R)...

Keywords: BHK cells, bradykinin receptor, glycosylation, localization, overexpression

05/2006 | Biological Chemistry, Walter de Gruyter

C. elegans as a model system to study the function of the COG complex in animal development

The conserved oligomeric Golgi (COG) complex is an octameric protein complex associated with the Golgi apparatus and is required for proper sorting and glycosylation of Golgi resident enzymes and secreted proteins...

Keywords: ADAM protease, Caenorhabditis elegans, COG complex, glycosylation, Golgi enzyme, organogenesis

08/2006 | Biological Chemistry, Walter de Gruyter

Tripeptidyl-peptidase I in health and disease

The lysosomal lumen contains numerous acidic hydrolases involved in the degradation of carbohydrates, lipids, proteins, and nucleic acids, which are basic cell components that turn over continuously within the cell and/or are ingested from outside of the cell...

Keywords: autoactivation, glycosylation, lysosomal aminopeptidase, lysosomal storage disorder, neuronal ceroid lipofuscinoses, sedolisin

08/2006 | Biological Chemistry, Walter de Gruyter

Synthesis and characterization of a functional intact IgG in a prokaryotic cell-free expression system

Antibodies are an important component of the immune system of higher eukaryotes. Furthermore, they are effective tools in basic research, medical diagnostics and therapy...

Keywords: antibody stability, cell-free expression system, Escherichia coli lysate, glycosylation, IgG1, MAK33, protein disulfide isomerase