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Items for "Glycosaminoglycans"

Fucosylated chondroitin sulfate as a new oral antithrombotic agent

Fucosylated chondroitin sulfate is a potent anticoagulant polysaccharide extracted from sea cucumber...

Keywords: Glycosaminoglycans, fucosylated chondroitin sulfate, oral anticoagulants, heparin

12/2006 | Thrombosis and Haemostasis, Schattauer

Heparin modulation of human plasma kallikrein on different substrates and inhibitors

The interplay of different proteases and glycosaminoglycans is able to modulate the activity of the enzymes and to affect their structures...

Keywords: Antithrombin, C1-inhibitor, Factor XII, Glycosaminoglycans, plasminogen, synthetic substrates

08/2006 | Biological Chemistry, Walter de Gruyter

Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control

Disturbed metabolism of glycosaminoglycans (GAGs) has been proposed to play an important role in the pathogenesis of late diabetic complications...

Keywords: extracellular matrix degradation, Glycosaminoglycans, lysosomal glycohydrolases, metabolic control, type 2 diabetes mellitus, vascular complications

09/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Alterations in serum glycosaminoglycan profiles in Graves' patients

Background: Qualitative and quantitative analyses of glycosaminoglycans (GAGs) in serum obtained from Graves' disease (GD) patients without extrathyroidal complications were carried out to provide a clearer understanding of the role of these macromolecules in the disease pathogenesis.

Methods: GAGs were isolated from serum of 17 GD patients before treatment and after attainment of the euthyroid state, as well as from 20 healthy individuals...

Keywords: chondroitin sulfate, dermatan sulfate, Glycosaminoglycans, heparan sulfate/heparin

05/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Fine characterization of mitral valve glycosaminoglycans and their modification with degenerative disease

Background: The levels and fine structure of complex polysaccharides, glycosaminoglycans (GAGs), were determined in segments of the posterior mitral valve leaflet (MVL) taken from 15 patients affected by mitral regurgitation and degenerative disease and were compared with segments from 15 multiorgan donors.

Methods: MVL GAGs were analyzed by agarose gel electrophoresis, and by HPLC and fluorophore-assisted carbohydrate electrophoresis to evaluate disaccharide patterns after treatment with chondroitinase ABC.

Results: GAGs from the control group were composed of approximately 37% hyaluronic acid and 63% chondroitin sulfate/dermatan sulfate with a charge density of approximately 0.61...

Keywords: chondroitin sulfate, degenerative disease, Glycosaminoglycans, Hyaluronic acid, mitral valve

03/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter