Items for "glycoprotein IIb/IIIa antagonist"

Utility of PFA-100^® closure time vs. optical aggregometry in assessing the efficacy of platelet membrane glycoprotein IIb/IIIa antagonists in vitro

Background: Closure time measured by a platelet function analyser (PFA-100^®) was examined for its usefulness in assessing the efficacy of platelet membrane glycoprotein IIb/IIIa antagonists in vitro, and was compared to optical platelet aggregometry.

Methods: Three known glycoprotein IIb/IIIa antagonists [H-Arg-Gly-Asp-Ser-OH (RGDS), tirofiban and eptifibatide] and six new peptidomimetic glycoprotein IIb/IIIa antagonists (DKT-59, DPS-172, SMA-101, SMA-104, SMA-179 and SKN-191) were assessed...

Keywords: closure time, glycoprotein IIb/IIIa antagonist, peptidomimetic, platelet aggregation, platelet function analyser