Items for "glutathione S-transferase M1, P1, T1"

Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers

Background: Cytochrome P450 (CYP) and glutathione S-transferase (GST) gene variants have been intensively investigated for their implication in the development of different neoplasms.

Methods: In the present study, we analyzed genetic polymorphisms of CYP1A1, GSTM1, GSTP1, and GSTT1 in 127 head and neck cancer patients and 151 hospital controls.

Results: No significant increase in risk in patients with the GSTM1 null genotype (OR=1.52, 95% CI: 0.93–2.49) or CYP1A1 462Val alleles (OR=1.60, 95% CI: 0.73–3.52) or GSTP1 105Val alleles (OR=0.97, 95% CI: 0.59–1.58) was observed...

Keywords: cytochrome P450 1A1, genetic polymorphism, glutathione S-transferase M1, P1, T1, head and neck cancer