Glutaminyl cyclases (QCs) catalyze the formation of pyroglutamic acid at the N-terminus of several peptides and proteins...
Keywords: glutaminyl cyclase, pathogenesis-related proteins, pyroglutamic acid
02/2007 | Biological Chemistry, Walter de GruyterThis highlight article describes three Alzheimer's disease (AD) studies presented at the 5th General Meeting of the International Proteolysis Society that address enzymatic mechanisms for producing neurotoxic ?-amyloid (A?) peptides...
Keywords: ?-amyloid, ?-secretase, cathepsins, glutaminyl cyclase, Inhibitors
08/2008 | Biological Chemistry, Walter de Gruyter