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Items for "glucose tolerance"

Prevention of diabetes mellitus: The future of German diabetology

One of the challenges in clinical diabetology today is to develop and implement diabetes prevention management programs for clinical practice...

Keywords: Diabetes mellitus, Glukosetoleranz, Lebensstilintervention Typ-2-Diabetes, nationales Programm

01/2007 | Hämostaseologie, Schattauer
Tiplaxtinin impairs nutritionally induced obesity in mice

To investigate the effect of tiplaxtinin, designed as a synthetic inhibitor of plasminogen activator inhibitor-1 (PAI-1), on obesity, male C57Bl/6 mice (13-14 weeks old) were kept on a high-fat diet (20.1 kJ/g) for four weeks without or with addition of tiplaxtinin (PAI-039) at a dose of 2 mg/g food...

Keywords: PAI-1, obesity, adipose tissue, glucose tolerance, insulin sensitivity

12/2006 | Thrombosis and Haemostasis, Schattauer
Sub-chronic administration of the 11?-HSD1 inhibitor, carbenoxolone, improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity

We have examined the metabolic effects of daily administration of carbenoxolone (CBX), a naturally occurring 11?-hydroxysteroid dehydrogenase (11?-HSD1) inhibitor, in mice with high fat diet-induced insulin resistance and obesity...

Keywords: carbenoxolone (CBX), glucose tolerance, 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1), insulin sensitivity, obesity, type 2 diabetes

04/2008 | Biological Chemistry, Walter de Gruyter