One of the challenges in clinical diabetology today is to develop and implement diabetes prevention management programs for clinical practice...
Keywords: Diabetes mellitus, Glukosetoleranz, Lebensstilintervention Typ-2-Diabetes, nationales Programm
01/2007 | Hämostaseologie, SchattauerTo investigate the effect of tiplaxtinin, designed as a synthetic inhibitor of plasminogen activator inhibitor-1 (PAI-1), on obesity, male C57Bl/6 mice (13-14 weeks old) were kept on a high-fat diet (20.1 kJ/g) for four weeks without or with addition of tiplaxtinin (PAI-039) at a dose of 2 mg/g food...
Keywords: PAI-1, obesity, adipose tissue, glucose tolerance, insulin sensitivity
12/2006 | Thrombosis and Haemostasis, SchattauerWe have examined the metabolic effects of daily administration of carbenoxolone (CBX), a naturally occurring 11?-hydroxysteroid dehydrogenase (11?-HSD1) inhibitor, in mice with high fat diet-induced insulin resistance and obesity...
Keywords: carbenoxolone (CBX), glucose tolerance, 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1), insulin sensitivity, obesity, type 2 diabetes
04/2008 | Biological Chemistry, Walter de Gruyter