Items for "GIP receptor antagonists"

Characterisation and glucoregulatory actions of a novel acylated form of the (Pro³)GIP receptor antagonist in type 2 diabetes

In this study, we tested the biological activity of a novel acylated form of (Pro³)glucose-dependent insulinotropic polypetide [(Pro³)GIP] prepared by conjugating palmitic acid to Lys¹⁶ to enhance its efficacy in vivo by promoting binding to albumin and extending its biological actions...

Keywords: antihyperglycaemic activity, DPP IV, fatty acid-linked peptides, GIP receptor antagonists, insulin secretion, obese diabetic (ob/ob) mice