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Items for "genotype"

Current and future prospects in haemostasis

Solving the human genome and new technical tools are nowadays rapidly increasing the knowledge of haemostasis...

Keywords: Phänotyp, Genotyp, Vitamin-K-Zyklus, Antikoagulanzien, Aptamere

01/2006 | Hämostaseologie, Schattauer
From Phenotype to Genotype: Issues in Navigating the Available Information Resources

OBJECTIVES: As part of an investigation of connecting health professionals and the lay public to both disease and genomic information, we assessed the availability and nature of the data from the Human Genome Project relating to human genetic diseases. METHODS: We focused on a set of single gene diseases selected from main topics in MEDLINEplus, the NLM's principal resource focused on consumers...

Keywords: Phenotype, genotype, databases (genetic), computa-tional navigation, information systems, Interoperability

01/2003 | Methods of Information in Medicine, Schattauer
Integration of Genomic Data in Electronic Health Records Opportunities and Dilemmas

Objectives: In this paper we give an overview about the challenge the postgenomic era poses on biomedical informaticists...

Keywords: Human genome, Phenotype, genotype, personal health record, Hospital Information Systems, Medical Informatics, bioinformatics

01/2005 | Methods of Information in Medicine, Schattauer
Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients

The antiplatelet effect of aspirin varies individually. This study evaluated whether the antiplatelet effect of aspirin associates with polymorphisms in the genes coding for cyclo-oxygenase-1 (COX-1) and several platelet glycoprotein (GP) receptors in patients with stable coronary artery disease (CAD)...

Keywords: Aspirin, cyclo-oxygenase-1, genotype, glycoprotein VI, coronary artery disease

00/0000 | Thrombosis and Haemostasis, Schattauer
Simultaneous analysis of MDR1 C3435T, G2677T/A, and C1236T genotypes by multiplexed mutagenically separated PCR

P-Glycoprotein (PGP) encoded by the multi-drug-resistance 1 ( MDR1) gene is a member of theATP-binding cassette (ABC) transporter family, drug-transporting proteins involved in the bioavailability and pharmacokinetics of various drugs...

Keywords: genotype, multi-drug-resistance 1 ( MDR1) gene, multiplex PCR, Polymorphism, ATP-binding cassette-(ABC)

04/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Apolipoprotein B gene 3?VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese

Background: Studies that considered polymorphisms within the apolipoprotein B (APOB) gene as risk factors for coronary heart disease (CHD) have reported conflicting results.

Methods: The phenotypic effects of the 3?VNTR polymorphism of the APOB gene on the susceptibility to CHD were investigated in 120 unrelated healthy individuals and 137 CHD patients...

Keywords: apolipoprotein B, Chinese, coronary heart disease, genotype, Polymorphism

10/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
The puzzle of the hepatitis B genotype distribution and evolution in Africa / Das Rätsel der Verbreitung und Evolution der Hepatitis B-Genotypen in Afrika

The hepatitis B virus (HBV) is currently estimated to chronically infect almost 400 million people worldwide of which 65 millions live on the African continent...

Keywords: Africa, epidemiology, genotype, hepatitis B virus, subtype, Afrika, Epidemiologie, Genotyp, Hepatitis B-Virus, Subtyp

07/2008 | LaboratoriumsMedizin, Walter de Gruyter
Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study

Background: The aim of this pilot study was to evaluate the relationship between interleukin-6 promoter –174G/C (IL-6 –174G/C) polymorphism and insulin resistance (IR) in obese patients with coronary heart disease (CHD).

Methods: Twenty obese male patients with CHD were selected from a larger database of patients (n=606)...

Keywords: adiposity, coronary heart disease, genotype, high-density lipoprotein cholesterol, insulin resistance, Interleukin-6

09/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter