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Items for "genetic polymorphism"

The genetic polymorphisms of β3-adrenergic receptor (AR) Trp64Arg and β2-AR Gln27Glu are associated with obesity in Chinese male hypertensive patients

Background: Genetic polymorphisms of β3-adrenergic receptor (AR) Trp64Arg and β2-AR Gln27Glu may result in significant change in the functions of these receptors...

Keywords: 2-adrenergic receptor, 3-adrenergic receptor, genetic polymorphism, haplotype, obesity

04/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Pharmacogenomics and adverse drug reactions in diagnostic and clinical practice

Pharmacogenetics and pharmacogenomics deal with genetically determined variations in how individuals respond to drugs...

Keywords: adverse drug reactions, CYP2D6, CYP2C9, CYP2C19, genetic polymorphism, pharmacogenetics, pharmacogenomics, therapeutic drug monitoring, thiopurine S-methyltransferase (TPMT), uridine diphosphate glucuronosyltransferase (UGT1A1)

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Alcohol and gene interactions

Alcohol use produces both desirable and undesirable effects, ranging from short-term euphoria and reduction in cardiovascular risk, to violence, accidents, dependence and liver disease...

Keywords: alcohol drinking, alcoholism, genetic linkage, genetic polymorphism, genetic variation

05/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Association of cytochrome P450 2E1 genetic polymorphisms with squamous cell carcinoma of the oesophagus

Squamous cell carcinoma of the oesophagus is one of the most common cancers among black males in South Africa...

Keywords: cytochrome P450 2E1, genetic polymorphism, oesophageal cancer

04/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

?2-adrenergic receptor gene polymorphisms and pregnancy outcome

Aims: The association between alleles at two loci of the polymorphic ?2-adrenergic receptor (?2AR) gene and pregnancy outcome was determined.

Methods: In a case-control study, buccal swabs obtained from 159 mother-infant pairs after a preterm or term birth were analyzed by gene amplification and endonuclease digestion for polymorphisms at codons 16 and 27 of the ?2AR gene.

Results: Homozygosity for allele A at codon 16 (Arg-16) occurred in 26 (20.5%) of 127 mothers with a term birth and in none of the mothers who had a spontaneous preterm birth (p = 0.002)...

Keywords: ?2-adrenergic receptor, genetic polymorphism, pregnancy, spontaneous preterm birth

09/2004 | Journal of Perinatal Medicine, Walter de Gruyter

Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer

Background: Alcohol is a major risk factor for susceptibility to oesophageal cancer in the South African population...

Keywords: alcohol dehydrogenases (ADH2, ADH3), aldehyde dehydrogenase (ALDH2), genetic polymorphism, oesophageal cancer, South African

03/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Relevance of glutathione S-transferase M1 and cytochrome P450 1A1 genetic polymorphisms to the development of head and neck cancers

Background: Cytochrome P450 (CYP) and glutathione S-transferase (GST) gene variants have been intensively investigated for their implication in the development of different neoplasms.

Methods: In the present study, we analyzed genetic polymorphisms of CYP1A1, GSTM1, GSTP1, and GSTT1 in 127 head and neck cancer patients and 151 hospital controls.

Results: No significant increase in risk in patients with the GSTM1 null genotype (OR=1.52, 95% CI: 0.93–2.49) or CYP1A1 462Val alleles (OR=1.60, 95% CI: 0.73–3.52) or GSTP1 105Val alleles (OR=0.97, 95% CI: 0.59–1.58) was observed...

Keywords: cytochrome P450 1A1, genetic polymorphism, glutathione S-transferase M1, P1, T1, head and neck cancer

08/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

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