OBJECTIVES: Clinical trials with correlated response data based on generalized estimating equations (GEE) have become increasingly popular as they require smaller samples than classical methods that ignore the clustered nature of the data...
Keywords: Sample size calculation, controlled clinical trials, generalized estimating equations, SAS software
01/2004 | Methods of Information in Medicine, SchattauerOBJECTIVES: The application of independence estimating equations (IEE) for controlled clinical trials (CCTs) has recently been discussed, and recommendations for its use have been derived for testing hypotheses...
Keywords: Small sample size, controlled clinical trials, generalized estimating equations, independence estimating equations
01/2006 | Methods of Information in Medicine, Schattauer