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Items for "gap junction"

Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells

Exposure of rat liver epithelial cells to doxorubicin, an anthraquinone derivative widely employed in cancer chemotherapy, led to a dose-dependent decrease in gap junctional intercellular communication (GJC)...

Keywords: connexin-43, extracellular signal-regulated kinase (ERK), gap junction, mitogen-activated protein (MAP) kinase, oxidative stress, signal transduction, stress signaling

03/2005 | Biological Chemistry, Walter de Gruyter
The gating effect of calmodulin and calcium on the connexin50 hemichannel

Gap junction channels formed by connexin50 (Cx50) are critical for the maintenance of eye lens transparency, which is sensitive to pH and external Ca2+ concentration, but the mechanism is still not clear...

Keywords: calcium, calmodulin, connexin50, gap junction, hemichannel, patch clamp

05/2006 | Biological Chemistry, Walter de Gruyter