Items for "fusion inhibitors"

A fluorescence assay for rapid detection of ligand binding affinity to HIV-1 gp41

The fusion-active conformation of the envelope protein gp41 of HIV-1 consists of an N-terminal trimeric ?-helical coiled-coil domain and three anti-parallel C-terminal helices that fold down the grooves of the coiled-coil to form a six-helix bundle...

Keywords: Fluorescence, fusion inhibitors, gp41 peptides, high-throughput screening, metal ion ligation