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Items for "free radicals"

Kinetic characterization of phenol and aniline derivates as substrates of peroxidase

The kinetic characterization of horseradish peroxidase (HRPC) substrates is difficult because the reaction products are free radicals...

Keywords: Anilines, ascorbic acid, free radicals, peroxidase, Phenols, steady-state kinetics

09/2004 | Biological Chemistry, Walter de Gruyter

Stereospecificity of horseradish peroxidase

We report here on the stereospecificity observed in the action of horseradish peroxidase (HRPC) on monophenol and diphenol substrates...

Keywords: ascorbic acid, free radicals, isomers, peroxidase, Phenols, steady-state kinetics

12/2004 | Biological Chemistry, Walter de Gruyter

Tumor necrosis factor-? and oxidant status are essential participating factors in unexplained recurrent spontaneous abortions

Background: Many factors have been implicated in the pathogenesis of unexplained recurrent spontaneous abortion (URSA)...

Keywords: antioxidant, free radicals, miscarriage, tumor necrosis factor-?, unexplained recurrent spontaneous abortion

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Isotretinoin therapy induces DNA oxidative damage

Background: Isotretinoin (Iso) is currently indicated for the treatment of cystic acne (CA) and is related to marked teratogenicity.

Aim: The aim of the study was to evaluate the relationship between total antioxidant status (TAS) and a serum marker of DNA oxidative damage, 8-hydroxy-2-desoxyguanosine (8-OHdG), in patients on Iso treatment.

Patients and methods: Patients with CA (n=18) were evaluated before and 45 days after Iso (0.5mg/kg per day) treatment and non-diseased controls (n=22) were tested only once...

Keywords: cystic acne, DNA damage, free radicals, 8-hydroxy-2-desoxyguanosine (8-OhdG), isotretinoin

11/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Lipid peroxidation in Down syndrome caused by regular trisomy 21, trisomy 21 by Robertsonian translocation and mosaic trisomy 21

Background: It has been suggested that an increase in oxidative stress in individuals with Down syndrome (DS) may cause adverse effects in the cell membranes through the oxidation of polyunsatured fatty acids.

Methods: We examined erythrocyte malondialdehyde (MDA) levels in 100 individuals of both sexes (34 males and 66 females) with DS, aged from newborn to 29 years...

Keywords: Down syndrome, free radicals, lipid peroxidation, malondialdehyde, oxidative stress

01/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Developing environmentally benign and effective organic wood preservatives by understanding the biocidal and non-biocidal properties of extractives in naturally durable heartwood

Wood products for exterior residential applications have long been protected with metallic preservatives...

Keywords: antioxidant activity, chromones, decay fungi, flavones, Fe3+ reducing activity, free radicals, fungicidal activity, heartwood, metal chelation, natural durability, organic biocides, wood preservation

05/2008 | Holzforschung, Walter de Gruyter

Modulation of longevity-associated genes by estrogens or phytoestrogens

Females live longer than males. We have shown that the higher levels of estrogens in females protect them against aging, by up-regulating the expression of antioxidant, longevity-related genes, such as that of selenium-dependent glutathione peroxidase (GPx) and Mn-superoxide dismutase (Mn-SOD)...

Keywords: aging, antioxidant enzymes, estrogenic compounds, free radicals, gender, oxidative stress

03/2008 | Biological Chemistry, Walter de Gruyter

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