Items for "folate"

Association of homocysteine (but not of MTHFR 677 C>T, MTR 2756 A>G, MTRR 66 A>G and TCN2 776 C>G) with ischaemic cerebrovascular disease in Sicily

Association between methylenetetrahydrofolate reductase polymorphism (MTHFR 677 C>T ), a determinant of homocysteine plasma level (t-Hcys), with ischaemc cerebrovascular disease (iCVD) seems to be neutral in North Europe and North America...

Keywords: Cerebrovascular disease, folate, homocysteine, methionine synthase reductase, methylenetetrahydrofolate reductase, transcobalamin

Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke

The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 677C?T polymorphism causes an A222V amino acid change which affects MTHFR enzyme activity and can increase homocysteine, a vascular disease risk factor...

Keywords: elderly, folate, methylenetetrahydrofolate reductase (MTHFR), mutation, Polymorphism, Stroke

Vitamin B₁₂ deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population

Prevalence rates for folate deficiency and hyperhomocysteinemia have been markedly reduced following the introduction of folic acid fortification in the United States...

Keywords: folate, fortification, homocysteine, transcobalamin, vitamin B12, PAR%, population attributable risk percentage, SALSA, Sacramento Area Latino Study on Aging

Betaine: a key modulator of one-carbon metabolism and homocysteine status

Betaine serves as a methyl donor in a reaction converting homocysteine to methionine, catalysed by the enzyme betaine-homocysteine methyltransferase...

Keywords: betaine, choline, dimethylglycine, folate, homocysteine

Homocysteine, type 2 diabetes mellitus, and cognitive performance: The Maine-Syracuse Study

Type 2 diabetes mellitus and higher total plasma homocysteine concentrations are each associated with an increased incidence of cardiovascular disease and with diminished cognitive performance...

Keywords: cardiovascular risk factors, cognitive performance, Diabetes mellitus, folate, homocysteine, vitamin B12, vitamin B6

Interactions between folate and aging for carcinogenesis

Inadequate folate intake and aging are each strongly implicated as important risk factors for certain cancers...

Keywords: aging, carcinogenesis, DNA methylation, folate, one-carbon metabolism, uracil misincorporation into DNA

Quantitative determination of erythrocyte folate vitamer distribution by liquid chromatography-tandem mass spectrometry

Background: Given the role of folate in many disorders, intracellular distribution of folate vitamers is of potential clinical importance...

Keywords: erythrocyte, folate, folate vitamer, liquid chromatography, Mass spectrometry

Hyperhomocysteinaemia and immune activation in patients with cancer

Background: Recently, homocysteine production was observed in tumour cell lines and homocysteine was proposed as a tumour marker...

Keywords: Cancer, cysteine, folate, homocysteine, inflammation, neopterin, vitamin B12

Association of vitamin B₁₂, folate and homocysteine with functional and pathological characteristics of the elderly in a mountainous village in Sicily

Background: Homocysteine is associated with age, folate and vitamin B₁₂...

Keywords: aging, folate, peripheral arteriopathy, Stroke, vitamin B12

Evaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults

Background: Since atherosclerosis is a slowly progressive process at a young age, effective preventive measures should be taken early in life to prevent future events associated with cardiovascular disease.

Methods: The study population comprised 132 young Japanese adults (mean age 21.4 years, range 18–31 years)...

Keywords: atherosclerosis, cardio-ankle vascular index, carotid intima-media thickness, folate, homocysteine, young adults

Plasma protein homocysteinylation in uremia

Protein homocysteinylation is proposed as one of the mechanisms of homocysteine toxicity...

Keywords: Albumin, folate, Hemodialysis, homocysteine, protein homocysteinylation, uremia

Biomarkers of folate and vitamin B₁₂ status in cerebrospinal fluid

Folate and vitamin B₁₂ are essential cofactors for the methionine/homocysteine cycle in the brain...

Keywords: cobalamin, folate, homocysteine, methyl

The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial

Background: Hyperhomocysteinemia is a new risk factor for osteoporosis...

Keywords: bone mineral density, C-terminal telopeptides of collagen I (CTx), folate, homocysteine, osteocalcin, pro-collagen type I N-terminal peptide (PINP), tartrate-resistant acid phosphatase (TRAP), urinary desoxypyridinoline cross-links (DPD), vitamin B6, vitamin B12

Quantitative profiling of folate and one-carbon metabolism in large-scale epidemiological studies by mass spectrometry

Background: Derangements of one-carbon metabolism have been related to the development of chronic diseases...

Keywords: choline, folate, Mass spectrometry, one-carbon metabolism, riboflavin, vitamin B6

Small ubiquitin-like modifier-1 (SUMO-1) modification of thymidylate synthase and dihydrofolate reductase

Background: Impairments in folate-mediated one-carbon metabolism are associated with pathologies and developmental anomalies, including cardiovascular disease, cancer, neurological disorders and neural tube defects...

Keywords: cytoplasmic serine hydroxymethyltransferase, dihydrofolate reductase, folate, small ubiquitin-like modifier (SUMO), thymidylate, thymidylate synthase