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Items for "Fluorine-18"

Syntheses of two potential dopamine D4 receptor radioligands: 18F labelled chromeno[3,4-c]pyridin-5-ones

The dopamine D4 receptor is hypothesized to relate with the pathophysiology and pharmacotherapy of schizophrenia while its level in brain regions is much lower and to date no suitable tracer is available for the study of D4 receptor in vivo ...

Keywords: Fluorine-18, Chromeno[3,4-c]pyridin–5-ones, Radio-chemical synthesis, PET, Dopamine D4 receptor

02/2006 | Radiochimica Acta, Oldenbourg Wissenschaftsverlag
Preparation and radiosynthesis of [18F]FE@CFN (2-[18F]fluoroethyl 4-[N-(1-oxopropyl)-N-phenylamino]-1-(2-phenylethyl)-4-piperidinecarboxylate): a potential μ-opioid receptor imaging agent

PET imaging of the μ-opioid receptor (OR) is still restricted to [ 11C]carfentanil ([ 11C]CFN) but its use is limited due to its short half-life and high agonistic potency...

Keywords: Opioid receptor, Carfentanil, Fluorine-18, Fluoroalkylation, PET

01/2007 | Radiochimica Acta, Oldenbourg Wissenschaftsverlag
Gender dependent rate of metabolism of the opioid receptor-PET ligand [ 18 F]fluoroethyldiprenorphine

AIM: The morphinane-derivate 6-O-(2-[ 18 F]fluoroethyl)-6-O-desmethyldiprenorphine ([ 18 F]FDPN) is a nonselective opioid receptor ligand currently used in positron emission tomography (PET)...

Keywords: Fluor-18, Diprenorphin, PET, Metabolismus, geschlechtsspezifische Unterschiede, Modeling

01/2006 | Nuklearmedizin, Schattauer
Radiosynthesis of the adenosine A3 receptor ligand 5-(2-[18F]fluoroethyl) 2,4-diethyl-3-(ethylsulfanylcarbonyl)- 6-phenylpyridine-5-carboxylate ([18F]FE@SUPPY)

Since to date very limited information on the distribution and function of the adenosine A3 receptor is available, the development of a suitable radioligand is needed...

Keywords: Adenosine, PET, Receptor, Fluorine-18, radioligand

02/2008 | Radiochimica Acta, Oldenbourg Wissenschaftsverlag