The dopamine D4 receptor is hypothesized to relate with the pathophysiology and pharmacotherapy of schizophrenia while its level in brain regions is much lower and to date no suitable tracer is available for the study of D4 receptor in vivo ...
Keywords: Fluorine-18, Chromeno[3,4-c]pyridin–5-ones, Radio-chemical synthesis, PET, Dopamine D4 receptor
02/2006 | Radiochimica Acta, Oldenbourg WissenschaftsverlagPET imaging of the μ-opioid receptor (OR) is still restricted to [ 11C]carfentanil ([ 11C]CFN) but its use is limited due to its short half-life and high agonistic potency...
Keywords: Opioid receptor, Carfentanil, Fluorine-18, Fluoroalkylation, PET
01/2007 | Radiochimica Acta, Oldenbourg WissenschaftsverlagAIM: The morphinane-derivate 6-O-(2-[ 18 F]fluoroethyl)-6-O-desmethyldiprenorphine ([ 18 F]FDPN) is a nonselective opioid receptor ligand currently used in positron emission tomography (PET)...
Keywords: Fluor-18, Diprenorphin, PET, Metabolismus, geschlechtsspezifische Unterschiede, Modeling
01/2006 | Nuklearmedizin, SchattauerSince to date very limited information on the distribution and function of the adenosine A3 receptor is available, the development of a suitable radioligand is needed...
Keywords: Adenosine, PET, Receptor, Fluorine-18, radioligand
02/2008 | Radiochimica Acta, Oldenbourg Wissenschaftsverlag