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Items for "factor VIII"

Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg593 to Cys substitution

Inhibitory antibodies develop in approximately 25% of patients with severe hemophilia. A following treatment with factorVIII...

Keywords: Transgenic animals, haemophilia A / B, factor VIII

00/0000 | Thrombosis and Haemostasis, Schattauer

Comparison of three activated protein C resistance tests in the risk assessment of venous thrombosis in non-carriers of the factor V Leiden mutation

Activated protein C resistance (APCR), measured using the original assay described by Dahlbck, is a risk factor for venous thrombosis independent of the factor V Leiden (FVL) mutation...

Keywords: Venous thrombosis, activated protein C resistance, factor V Leiden, factor VIII

04/2006 | Thrombosis and Haemostasis, Schattauer

Recombinant factor VIII and factor VIII-von Willebrand factor complex do not present danger signals for human dendritic cells

Several lines of evidence have shown that antibody responses to coagulation factor VIII (FVIII) in patients with hemophilia A depend on the help of activated CD4+ T cells...

Keywords: Hemophilia A, FVIII inhibitors, human dendritic cells, danger signals, factor VIII

09/2006 | Thrombosis and Haemostasis, Schattauer

Evidence for the benefits of prophylaxis in the management of hemophilia A

The optimal treatment of hemophilia has been evolving since the advent of factor VIII concentrates, continues to vary geographically, and remains a source of debate...

Keywords: Hemophilia, prophylaxis, on-demand, factor VIII, arthropathy, cost-benefit

10/2006 | Thrombosis and Haemostasis, Schattauer

Haemophilia A: molecular insights

Haemophilia A is the most common inherited bleeding disorder caused by defects in the F8C gene that encodes coagulation factor VIII...

Keywords: factor VIII, haemophilia A, modifier genes, molecular analysis, prothrombotic gene variants

04/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter