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Items for "factor V Leiden"

No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study

Homocysteine may have a thrombogenic effect through inhibition of inactivation of factor Va by activated protein C...

Keywords: MTHFR, methylenetetrahydrofolatereductase, homocysteine, factor V Leiden, meta-analysis, case-only, case-control, VITRO

01/2007 | Thrombosis and Haemostasis, Schattauer

The procoagulant effects of factor V Leiden may be balanced against decreased levels of factor V and do not reflect in vivo thrombin formation in newborns

Thrombin regulation in newborns remains incompletely understood. We studied tissue factor-initiated thrombin formation in cord plasma in vitro, and the effects of Factor VLeiden (FVL) heterozygosity on thrombin regulation both in vitro and in vivo in newborns...

Keywords: Newborn, thrombin, activated protein C, factor V Leiden, platelet- rich plasma

03/2006 | Thrombosis and Haemostasis, Schattauer

Comparison of three activated protein C resistance tests in the risk assessment of venous thrombosis in non-carriers of the factor V Leiden mutation

Activated protein C resistance (APCR), measured using the original assay described by Dahlbck, is a risk factor for venous thrombosis independent of the factor V Leiden (FVL) mutation...

Keywords: Venous thrombosis, activated protein C resistance, factor V Leiden, factor VIII

04/2006 | Thrombosis and Haemostasis, Schattauer

Interleukin-10 promoter polymorphism and venous thrombosis: A case-control study

The human interleukin-10 promoter gene is highly polymorphic. IL-10 polymorphisms have been associated with various autoimmune and lymphoproliferative disorders...

Keywords: deep vein thrombosis, interleukin-10, factor V Leiden, hereditary thrombosis risk factor

07/2006 | Thrombosis and Haemostasis, Schattauer

Establishment of the 1 st International Genetic Reference Panel for Factor V Leiden, human gDNA

Forty-one laboratories participated in an international collaborative study to assess the suitability of a panel of three genomic DNA samples as the 1 st International Genetic Reference Panel for the Factor V Leiden (FVL) variant...

Keywords: factor V Leiden, genetic reference materials, genomic DNA, in vitro diagnostics

08/2006 | Thrombosis and Haemostasis, Schattauer

Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden

The factor V Leiden (FVL) mutation, a genetic abnormality with an autosomal mode of inheritance, is associated with an increased risk of venous thromboembolism (VTE)...

Keywords: Familial thrombosis, Venous thrombosis, factor V Leiden

12/2006 | Thrombosis and Haemostasis, Schattauer

High frequency of factor V Leiden in surgical patients with symptomatic venous thromboembolism despite prophylaxis

Among candidate risk factors associated with postoperative venous thromboembolism (VTE), the role of factorV Leiden (FVL) mutation remains unclear...

Keywords: Venous thromboembolism, pulmonary embolism, factor V Leiden, surgery, orthopaedic surgery, risk factors

00/0000 | Thrombosis and Haemostasis, Schattauer

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