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Items for "extracellular signal-regulated kinase (ERK)"

Oncogenic Ras in tumour progression and metastasis

The ras genes give rise to a family of related GTP-binding proteins that exhibit potent transforming potential...

Keywords: extracellular signal-regulated kinase (ERK), Migration, phosphatidylinositol 3-kinase (PI3-K), Rho GTPases, signal transduction, transformation

03/2005 | Biological Chemistry, Walter de Gruyter
Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells

Exposure of rat liver epithelial cells to doxorubicin, an anthraquinone derivative widely employed in cancer chemotherapy, led to a dose-dependent decrease in gap junctional intercellular communication (GJC)...

Keywords: connexin-43, extracellular signal-regulated kinase (ERK), gap junction, mitogen-activated protein (MAP) kinase, oxidative stress, signal transduction, stress signaling

03/2005 | Biological Chemistry, Walter de Gruyter
TGF?-induced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4

Advanced malignancies often exhibit increased concentrations of transforming growth factor-? (TGF?), which has been suggested to promote invasion and metastasis...

Keywords: epithelial dedifferentiation, extracellular signal-regulated kinase (ERK), focal complex formation, Rho-GTPases, signal transduction, transforming growth factor-? (TGF?)

03/2005 | Biological Chemistry, Walter de Gruyter