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Items for "extracellular matrix"

Morphology and transfection study of human microvascular endothelial cell angiogenesis: an in vitro three-dimensional model

Microvascular endothelial cells from human neonatal foreskin were grown in vitro until a three-dimensional network of capillary-like structures was formed...

Keywords: capillary-like structures, collagen IV, endothelial-specific promoters, extracellular matrix, human endothelium, transcription factor Ets-1

02/2005 | Biological Chemistry, Walter de Gruyter
Air pollution-associated fly ash particles induce fibrotic mechanisms in primary fibroblasts

Air pollution is associated with a variety of respiratory and cardiovascular disorders, including fibrosis...

Keywords: advanced glycation endproducts, extracellular matrix, fibrosis, oxidative stress, particulate matter

10/2006 | Biological Chemistry, Walter de Gruyter
Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins

Human kallikrein 4 (hK4) is a member of the expanded family of human kallikreins, a group of 15 secreted proteases...

Keywords: cancer metastasis, extracellular matrix, human kallikrein 4, ovarian cancer, prognostic markers, prostate cancer, serine protease, serine protease inhibitors

06/2006 | Biological Chemistry, Walter de Gruyter
The impact of aryl hydrocarbon receptor signaling on matrix metabolism: implications for development and disease

The aryl hydrocarbon receptor (AhR) was identified as the receptor for polycyclic aromatic hydrocarbons and related compounds...

Keywords: AhR, development, ECM, extracellular matrix, Matrix metalloproteinase, MMP, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

09/2006 | Biological Chemistry, Walter de Gruyter
Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells

Mesangial cells are thought to be important mediators of glomerular inflammation and fibrosis...

Keywords: connective tissue growth factor (CTGF), extracellular matrix, mesangial cells, nitric oxide, representational difference analysis (RDA), transcriptional regulation

05/2007 | Biological Chemistry, Walter de Gruyter
Serum levels of the osteoprotegerin, receptor activator of nuclear factor ?-B ligand, metalloproteinase-1 (MMP-1) and tissue inhibitors of MMP-1 levels are increased in men 6 months after acute myocardial infarction

Background: Osteoprotegerin (OPG) and receptor activator of nuclear factor ?-B ligand (RANKL) are critical regulators of bone remodeling and RANKL/RANK signaling could also play an important role in the remodeling process of several tissues, such as myocardium...

Keywords: extracellular matrix, matrix metalloproteinases, myocardial infarction, osteoprotegerin, receptor activator of nuclear factor ?-B ligand, tissue inhibitors of metalloproteinase

04/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Human monocytes augment invasiveness and proteolytic activity of inflammatory breast cancer

Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer, and here, we examined in vitro the interactions between the human IBC cell line SUM149 and U937 human naive monocytes...

Keywords: cathepsin B, caveolin-1, co-culture, extracellular matrix, proteolysis

08/2008 | Biological Chemistry, Walter de Gruyter
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17

Metalloproteases play a complex role in tumor progression. While the activity of some ADAM, ADAMTS and matrix metalloproteases (MMPs) seems to be protumorigenic, the activity of others seems to prevent tumor progression...

Keywords: extracellular matrix, GPI-anchored, metalloprotease, oncogenesis, proteomics, shedding

08/2008 | Biological Chemistry, Walter de Gruyter
Age-related changes of plasma glycosaminoglycans

Background: This study was undertaken to reveal how the physiological ageing process influences plasma glycosaminoglycans (GAGs) content and composition.

Methods: GAGs isolated from plasma samples obtained from 105 healthy subjects were quantified using a hexuronic acid assay and subjected to electrophoretic fractionation.

Results: We found that total GAGs decreased gradually with advancing age...

Keywords: ageing process, chondroitin sulfate, dermatan sulfate, extracellular matrix, heparin sulfate/heparin, plasma glycosaminoglycans

10/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Synergism between AT1 receptor and hyperhomocysteinemia during vascular remodeling

Background: Hyperhomocysteinemia (HHcy) is an independent risk factor of cardiovascular diseases...

Keywords: angiotensin II type 1 (AT1) receptor, collagen type-1, extracellular matrix, extracellular signal-regulated kinase-1/2 (ERK-1/2), matrix metalloproteinase-9 (MMP-9), signal transducer and activator of transcription-3 (STAT3)

12/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter