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Items for "Escherichia coli RNase P"

A 2′-methyl or 2′-methylene group at G+1 in precursor tRNA interferes with Mg2+ binding at the enzyme-substrate interface in E-S complexes of E. coli RNase P

We analyzed processing of precursor tRNAs carrying a single 2′-deoxy, 2′-OCH3, or locked nucleic acid (LNA) modification at G+1 by Escherichia coli RNase P RNA in the absence and presence of its protein cofactor...

Keywords: Escherichia coli RNase P, LNA (locked nucleic acid), 2-OCH3 substitutions at G+1 in the substrate, precursor tRNA processing

07/2007 | Biological Chemistry, Walter de Gruyter