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Items for "ERK"

Inhibition of inducible TNF-? expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale

In a search for compounds inhibiting the inducible TNF-?a promoter activity in T cells, a new spiro-compound, designated oxaspirodion, was isolated from fermentations of the ascomycete Chaetomium subspirale...

Keywords: ERK, NF-?B, oxaspirodion, TNF-? synthesis

09/2004 | Biological Chemistry, Walter de Gruyter

B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade

Signaling pathways based on the reversible phosphorylation of proteins control most aspects of cellular life in higher organisms...

Keywords: Cancer, ERK, hepatocytes, kinase, MEK, phosphatase, Raf, Ras, signaling

11/2005 | Biological Chemistry, Walter de Gruyter

Modulation of autocrine TNF-?-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells

Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins...

Keywords: cross-talk, ERK, gelatinase B, JNK, leukemia, p38

01/2006 | Biological Chemistry, Walter de Gruyter

Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway

KEPI is a protein kinase C-potentiated inhibitory protein for type 1 Ser/Thr protein phosphatases...

Keywords: breast tumorigenesis, EGR1, ERK, Gene expression, KEPI, PTEN

05/2007 | Biological Chemistry, Walter de Gruyter

Inhibition of inducible tumor necrosis factor-α expression by the fungal epipolythiodiketopiperazine gliovirin

TNF-α is a major pro-inflammatory cytokine that regulates further cytokine induction, especially of IL-1 and IL-6, in many human diseases including cancer, inflammation and immune disorders...

Keywords: ERK, gliovirin, IL-2 synthesis, inhibitor, NF-B, TNF- synthesis

06/2007 | Biological Chemistry, Walter de Gruyter