Items for "epithelial dedifferentiation"

TGF?-induced focal complex formation in epithelial cells is mediated by activated ERK and JNK MAP kinases and is independent of Smad4

Advanced malignancies often exhibit increased concentrations of transforming growth factor-? (TGF?), which has been suggested to promote invasion and metastasis...

Keywords: epithelial dedifferentiation, extracellular signal-regulated kinase (ERK), focal complex formation, Rho-GTPases, signal transduction, transforming growth factor-? (TGF?)