Items for "enzyme mechanisms"

Selenium in chemistry and biochemistry in comparison to sulfur

What makes selenoenzymes – seen from a chemists view – so special that they cannot be substituted by just more analogous or adapted sulfur proteins? This review compiles and compares physicochemical properties of selenium and sulfur, synthetic routes to selenocysteine (Sec) and its peptides, and comparative studies of relevant thiols and selenols and their (mixed) dichalcogens, required to understand the special role of selenium in selenoproteins on the atomic molecular level...

Keywords: disulfide/diselenide/selenenylsulfide interchange, enzyme mechanisms, selenocysteine, selenoproteins, Synthesis