The glyoxalase system consisting of glyoxalase I (GloI) and glyoxalase II (GloII) constitutes a glutathione-dependent intracellular pathway converting toxic 2-oxoaldehydes, such as methylglyoxal, to the corresponding 2-hydroxyacids...
Keywords: drug development, enzyme inhibition, glutathione derivatives, methylglyoxal, molecular modeling
01/2005 | Biological Chemistry, Walter de GruyterWe studied the effects of sulfur-containing chemopreventive agents, including allyl sulfides and isothiocyanates, on human redox networks...
Keywords: A549 cells, allyl sulfides, enzyme inhibition, isothiocyanates, redox networks, transcript levels
10/2007 | Biological Chemistry, Walter de Gruyter