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Items for "enzyme inhibition"

Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts

The glyoxalase system consisting of glyoxalase I (GloI) and glyoxalase II (GloII) constitutes a glutathione-dependent intracellular pathway converting toxic 2-oxoaldehydes, such as methylglyoxal, to the corresponding 2-hydroxyacids...

Keywords: drug development, enzyme inhibition, glutathione derivatives, methylglyoxal, molecular modeling

01/2005 | Biological Chemistry, Walter de Gruyter
Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents

We studied the effects of sulfur-containing chemopreventive agents, including allyl sulfides and isothiocyanates, on human redox networks...

Keywords: A549 cells, allyl sulfides, enzyme inhibition, isothiocyanates, redox networks, transcript levels

10/2007 | Biological Chemistry, Walter de Gruyter