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Items for "endothelium"
In vivo antithrombotic synergy of oral heparin and arginine: Endothelial thromboresistance without changes in coagulation parameters
On the basis of suggested clinical efficacy in an uncontrolled study in ninety-seven patients with unstable angina, an animal study was conducted to investigate antithrombotic synergy between orally administered heparin and arginine...
Keywords: heparin, thrombosis, endothelium, arginine, oral
05/2006 | Thrombosis and Haemostasis, SchattauerFibronectin binding proteins contribute to the adherence of Staphylococcus aureus to intact endothelium in vivo
Staphylococcal adhesins mediate attachment to matrix proteins and endothelial cells in vitro, yet, their role in primary adherence to the physiologic vessel wall has not been studied in vivo, and complex endocarditis models yielded ambiguous results...
Keywords: Staphylococcus aureus, endothelium, intravital fluorescence microscopy, fibronectin binding protein A, adherence
08/2006 | Thrombosis and Haemostasis, SchattauerFibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells
Surface molecules of Staphylococcus aureus are involved in the colonization of vascular endothelium which is a crucial primary event in the pathogenesis of infective endocarditis (IE)...
Keywords: Staphylococcus aureus, endocarditis, Coagulation, fibronectin binding protein A, endothelium, activation
04/2007 | Thrombosis and Haemostasis, SchattauerEndothelial mediators and communication through vascular gap junctions
Cellular interaction in vessels is achieved by multiple communication pathways, including gap junctions (GJs)...
Keywords: conducted response, connexin, EDHF, endothelium, gap junctions, microcirculation
01/2006 | Biological Chemistry, Walter de GruyterThe l -arginine nitric oxide pathway: avenue for a multiple-level approach to assess vascular function
Endothelial dysfunction is an early stage of atherosclerosis and has been attributed to impaired nitric oxide (NO) bioactivity and enhanced formation of oxygen-derived free radicals...
Keywords: biomarker, endothelial dysfunction, endothelium, nitrite, NOS
10/2006 | Biological Chemistry, Walter de GruyterWhich endothelium-derived factors are really important in humans?
The endothelium plays a primary role in the local control of vascular function and structure, mainly by the production and release of NO, a potent vasodilator that also inhibits all the mechanisms involved in the pathogenesis of atherosclerosis, thus protecting the vessel wall against the development of atherosclerosis and thrombosis...
Keywords: circulation, endothelium, nitric oxide, oxidative stress, vascular reactivity
02/2006 | Biological Chemistry, Walter de GruyterElevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality
The endothelium plays a crucial role in the maintenance of vascular tone and structure by releasing the endothelium-derived vasoactive mediator, nitric oxide (NO)...
Keywords: coronary heart disease, endothelium, nitric oxide, Prognosis, risk factors
10/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterHyperhomocysteinemia and cardiovascular risk in postmenopausal women: the role of folate supplementation
In the postmenopausal period, cardiovascular diseases are a frequent chronic condition leading to high risk of myocardial infarction and death...
Keywords: cardiovascular disease, endothelium, folate, homocysteine, postmenopausal
02/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterHeparinase selectively sheds heparan sulphate from the endothelial glycocalyx
A healthy vascular endothelium is coated by the endothelial glycocalyx. Its main constituents are transmembrane syndecans and bound heparan sulphates...
Keywords: coronary system, endothelium, heart, permeability barrier, syndecans
01/2008 | Biological Chemistry, Walter de Gruyter