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Items for "EM algorithm"

A Sequential Method for Discovering Probabilistic Motifs in Proteins

OBJECTIVES: This paper proposes a greedy algorithm for learning a mixture of motifs model through like-lihood maximization, in order to discover common substrings, known as motifs, from a given collection of related biosequences. METHODS: The approach sequentially adds a new motif component to a mixture model by performing a combined scheme of global and local search for appropriately initializing the component parameters...

Keywords: Motif discovery, mixture of motifs, EM algorithm, protein fingerprints, MEME algorithm

01/2004 | Methods of Information in Medicine, Schattauer
Estimation of Parameters in Shot-Noise-Driven Doubly Stochastic Poisson Processes Using the EM Algorithm Modeling of Pre- and Postsynaptic Spike Trains

OBJECTIVES: To estimate the parameters, the impulse response (IR) functions of some linear time-invariant systems generating intensity processes, in Shot-Noise-Driven Doubly Stochastic Poisson Process (SND-DSPP) in which multivariate presynaptic spike trains and postsynaptic spike trains can be assumed to be modeled by the SND-DSPPs...

Keywords: Random point process, EM algorithm, computer simulation, fluctuation, neural spike trains

01/2007 | Methods of Information in Medicine, Schattauer