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Items for "elderly"

Tinzaparin and enoxaparin given at prophylactic dose for eight days in medical elderly patients with impaired renal function. A comparative pharmacokinetic study

Low-molecular-weight heparins (LMWHs) accumulate in patients with impaired renal function. As this accumulation depends on heparin chain length and subsequent reticulo-endothelial/renal elimination, LMWHs might have different pharmacodynamic profiles...

Keywords: LMWHs, thromboprophylaxis, elderly, renal insufficiency

04/2007 | Thrombosis and Haemostasis, Schattauer

The uncoupling protein-1 gene ?3826A/G polymorphism and hypertension in Japanese subjects

Background: The possible effects of the uncoupling protein-1 (UCP-1) gene ?3826A/G polymorphism on hypertension (HT) have yet to be elucidated.

Methods: A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the ?3826A/G polymorphism by genomic PCR and Bcl1-restriction fragment length polymorphism methods.

Results: Multivariate logistic regression analysis for HT, adjusted for genotype (recessive model, AA+AG vs...

Keywords: blood pressure, elderly, gender, hypertension, single nucleotide polymorphisms (SNPs)

09/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Association of lipase lipoprotein polymorphisms with myocardial infarction and lipid levels

Background: Lipoprotein lipase has an important role in lipid metabolism...

Keywords: elderly, high-density lipoprotein, lipoprotein lipase, LPL HindIII polymorphism, LPL S447X polymorphism, myocardial infarction, triglyceride

05/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Methylenetetrahydrofolate reductase gene A222V polymorphism and risk of ischemic stroke

The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene 677C?T polymorphism causes an A222V amino acid change which affects MTHFR enzyme activity and can increase homocysteine, a vascular disease risk factor...

Keywords: elderly, folate, methylenetetrahydrofolate reductase (MTHFR), mutation, Polymorphism, Stroke

12/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

APO A-V–1131T?C polymorphism frequency and its association with morbidity in a Brazilian elderly population

Identification of genetic polymorphisms as risk factors for complex diseases affecting older people can be relevant for their prevention, diagnosis and management...

Keywords: ?1131T?C, APO A-V, elderly, morbidity, SNP3, Polymorphism

01/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Clinical chemistry reference values for 75-year-old apparently healthy persons

Background: Clinical chemistry reference values for elderly persons are sparse and mostly intermixed with those for younger subjects...

Keywords: clinical chemistry analytes, elderly, prognostic marker, reference interval

11/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Biochemical reference intervals for sex hormones with a new AutoDelfia method in aged men

Background: Our aim was to establish sex hormone reference intervals measured with a new AutoDelfia immunoassay method for aged men free of medication and/or conditions known to influence sex hormone levels.

Methods: The reference population consisted of 466 individuals between 64 and 97 years (mean 72 years) and a mean body mass index (BMI) of 26.9 kg/m².

Results and conclusions: Because age correlated significantly with most sex hormones studied, we calculated reference intervals for three age groups (64–69, 70–74 and ?75 years)...

Keywords: androgens, elderly, estrogens, men, reference interval, sex hormone-binding globulin

02/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study

Background: Aging is associated with low-grade elevation of circulating inflammatory markers, leading to increased risk of morbidity and mortality...

Keywords: elderly, inflammatory markers, Mediterranean diet, ZINCAGE study

07/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

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Items for "elderly"