LEKTI is a 120-kDa protein that plays an important role in skin development, as mutations affecting LEKTI synthesis underlie Netherton syndrome, an inherited skin disorder producing severe scaling...
Keywords: desquamation, Netherton syndrome, SPINK5, standard mechanism inhibitor
11/2005 | Biological Chemistry, Walter de GruyterWe have previously presented evidence that two human kallikrein-related peptidases, KLK5 (hK5, stratum corneum tryptic enzyme, SCTE) and KLK7 (hK7, stratum corneum chymotryptic enzyme, SCCE), which are abundant in the stratum corneum, may be involved in desquamation...
Keywords: desquamation, enzyme activity, hK5/KLK5/SCTE, hK7/KLK7/SCCE, hK14/KLK14, stratum corneum
06/2006 | Biological Chemistry, Walter de Gruyter