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Items for "desquamation"

Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI)

LEKTI is a 120-kDa protein that plays an important role in skin development, as mutations affecting LEKTI synthesis underlie Netherton syndrome, an inherited skin disorder producing severe scaling...

Keywords: desquamation, Netherton syndrome, SPINK5, standard mechanism inhibitor

11/2005 | Biological Chemistry, Walter de Gruyter
Kallikrein-related peptidase 14 may be a major contributor to trypsin-like proteolytic activity in human stratum corneum

We have previously presented evidence that two human kallikrein-related peptidases, KLK5 (hK5, stratum corneum tryptic enzyme, SCTE) and KLK7 (hK7, stratum corneum chymotryptic enzyme, SCCE), which are abundant in the stratum corneum, may be involved in desquamation...

Keywords: desquamation, enzyme activity, hK5/KLK5/SCTE, hK7/KLK7/SCCE, hK14/KLK14, stratum corneum

06/2006 | Biological Chemistry, Walter de Gruyter