Items for "cytochrome P450 (CYP450)"

Comparison of the TaqMan and LightCycler systems in pharmacogenetic testing: evaluation of CYP2C9*2/*3 polymorphisms

Background: Pharmacogenetic testing for drug-metabolizing enzymes is not yet widely used in clinical practice.

Methods: In an attempt to facilitate the application of this procedure, we have compared two real-time PCR-based methods, the TaqMan^® and the LightCycler? for the pharmacogenetic evaluation of CYP2C9*2/*3 polymorphisms.

Results and Conclusion: Both procedures are suitable for pharmacogenetic studies...

Keywords: cytochrome P450 (CYP450), pharmacogenetic testing, polymorphisms