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Items for "cytochrome P450"

Cytosolic persistence of mouse brain CYP1A1 in chronic heme deficiency

Previous work has demonstrated that the function of extrahepatic cytochrome P450 CYP1A1 is dependent on the availability of heme...

Keywords: apoprotein, cytochrome P450, membrane insertion, porphyria, transgenic mouse

11/2005 | Biological Chemistry, Walter de Gruyter

Inhibition of aldosterone biosynthesis by staurosporine

Staurosporine (STS) is a very potent broad-range kinase inhibitor, and its antiproliferative properties made it a lead compound for protein kinase C (PKC) inhibitors with therapeutic potential...

Keywords: adrenodoxin, aldosterone, blood pressure, CYP11B2, cytochrome P450, protein kinase inhibitor, staurosporine, steroid hydroxylation

07/2005 | Biological Chemistry, Walter de Gruyter

Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria

Mitochondrial cytochrome P450 systems are an indispensable component of mammalian steroid biosynthesis; they catalyze regio- and stereo-specific steroid hydroxylations and consist of three protein entities: adrenodoxin reductase (AdR), adrenodoxin (Adx), and a mitochondrial cytochrome P450 enzyme, e.g., CYP11A1 (P450 side chain cleavage, P450scc)...

Keywords: adrenodoxin, Apoptosis, CYP11A1, cytochrome P450, electron transfer chain, mitochondria, reactive oxygen species, steroid hydroxylation

05/2005 | Biological Chemistry, Walter de Gruyter

Therapeutic drug monitoring of non-tricyclic antidepressant drugs

Therapeutic drug monitoring (TDM) of many of the tricyclic antidepressants (TCAs) has been demonstrated to be of clear clinical value...

Keywords: cytochrome P450, non-tricyclic antidepressant, selective serotonin reuptake inhibitors (SSRIs), therapeutic drug monitoring, venlafaxine

11/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

CYP2C8 polymorphism among the Portuguese

Cytochrome P450 2C8 (CYP2C8) is a polymorphic phase I drug-metabolising enzyme involved in the metabolism of a wide variety of xenobiotics, as well as a proposed player in the regulation of vascular tone...

Keywords: allele, CYP2C8, cytochrome P450, Polymorphism, Portugal

02/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter