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Items for "cysteine protease"

Inhibition of cathepsin B reduces ?-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate ?-secretase of Alzheimer's disease

The regulated secretory pathway of neurons is the major source of extracellular A? that accumulates in Alzheimer's disease (AD)...

Keywords: ?-amyloid, ?-secretase, cathepsin B, cysteine protease, regulated secretory pathway

09/2005 | Biological Chemistry, Walter de Gruyter

Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice

The cysteine protease dipeptidyl peptidase I (DPPI) activates granule-associated immune-cell serine proteases...

Keywords: chymase, cysteine protease, mast cell, papain

08/2006 | Biological Chemistry, Walter de Gruyter

Cysteine protease inhibitors reduce brain ?-amyloid and ?-secretase activity in vivo and are potential Alzheimer's disease therapeutics

?-Secretase inhibitors that lower brain ?-amyloid peptides (A?) are likely to be effective for treating Alzheimer's disease (AD)...

Keywords: A?, Ac-LVK-CHO, ?-amyloid, ?-secretase, cathepsin B, cysteine protease, inhibitor

09/2007 | Biological Chemistry, Walter de Gruyter

Two decades of thyroglobulin type-1 domain research

Thyroglobulin type-1 repeats are primarily found in thyroglobulin and several other functionally unrelated proteins...

Keywords: cysteine protease, equistatin, IGFBP, invariant chain, p41 fragment, thyropin

11/2007 | Biological Chemistry, Walter de Gruyter

Inhibition of human ?-calpain by conformationally constrained calpastatin peptides

The 27-mer peptide CP1B-[1–27] derived from exon 1B of calpastatin stands out among the known inhibitors for ?- and m-calpain due to its high potency and selectivity...

Keywords: cysteine protease, macrolactamization, peptidomimetic, protease inhibitor

01/2008 | Biological Chemistry, Walter de Gruyter