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Items for "cysteine peptidases"

Dual concentration-dependent activity of thyroglobulin type-1 domain of testican: specific inhibitor and substrate of cathepsin L

The thyroglobulin type-1 (Tg-1) domain is a protein module that occurs in a variety of secreted and membrane proteins and is recognised as a potent inhibitor of cysteine peptidases...

Keywords: cysteine peptidases, extracellular proteolysis, inhibition kinetics, proteoglycans, testican, thyropin

01/2005 | Biological Chemistry, Walter de Gruyter

Regulation of human cathepsin B by alternative mRNA splicing: homeostasis, fatal errors and cell death

One of the control mechanisms of cathepsin B biosynthesis and trafficking operates through alternative splicing of pre-mRNA...

Keywords: cysteine peptidases, mitochondria, overexpression, trafficking, unfolded protein, untranslated region

08/2006 | Biological Chemistry, Walter de Gruyter

Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B

Of seven human cystatins investigated, none inhibited the cysteine proteases staphopain A and B secreted by the human pathogen Staphylococcus aureus...

Keywords: cysteine peptidases, protease inhibitors, Staphylococcus aureus, virulence factors

04/2007 | Biological Chemistry, Walter de Gruyter

Intestine-specific expression of green fluorescent protein-tagged cathepsin B: proof-of-principle experiments

We hypothesized that tissue-specific expression of cathepsin B-enhanced green fluorescent protein (CB-EGFP) can be driven by the A33-antigen promoter that contains positive cis-regulatory elements, including caudal-related homeobox (CDX) binding sites...

Keywords: A33-antigen promoter, Cdx1, cysteine peptidases, green fluorescent protein, intestine, trafficking