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Items for "CYP2D6"

Pharmacogenomics and adverse drug reactions in diagnostic and clinical practice

Pharmacogenetics and pharmacogenomics deal with genetically determined variations in how individuals respond to drugs...

Keywords: adverse drug reactions, CYP2D6, CYP2C9, CYP2C19, genetic polymorphism, pharmacogenetics, pharmacogenomics, therapeutic drug monitoring, thiopurine S-methyltransferase (TPMT), uridine diphosphate glucuronosyltransferase (UGT1A1)

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship

The drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several clinically important drugs...

Keywords: CYP2D6, debrisoquine, HPLC, metabolic ratio

03/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter