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Items for "coronary heart disease"

The Framingham Risk Function Underestimated Absolute Coronary Heart Disease Risk in Czech Men

OBJECTIVES: The aim was to validate the Framingham coronary heart disease (CHD) risk function with the formula by Wilson et al...

Keywords: External validation, Framingham risk function, coronary heart disease

01/2007 | Methods of Information in Medicine, Schattauer
Gaining Insight from Flexible Models Assessment of the Secondary Prevention Trial of CHD in the Czech Male Population with MI History

Objectives: We present results from a secondary prevention trial of coronary heart disease (CHD) in the Czech male population from northern Bohemia with the history of myocardial infarction (MI) and high prevalence of metabolic syndrome...

Keywords: coronary heart disease, non-proportional hazards, secondary prevention, survival

01/2006 | Methods of Information in Medicine, Schattauer
Assessment of genetic risk for myocardial infarction

Although lifestyle and environmental factors influence the prevalence of myocardial infarction, genetic epidemiological studies have suggested that several genetic variants increase the risk for this condition...

Keywords: genetics, Polymorphism, myocardial infarction, coronary heart disease, atherosclerosis

08/2006 | Thrombosis and Haemostasis, Schattauer
Antioxidant capacity of the human pericardial fluid: does gender have a role?

The aim of the present study was to assess the antioxidant capacity in the serum and pericardial fluid of patients undergoing heart surgery for coronary heart disease (CHD) or valvular heart disease (VHD) and to find out whether there are gender-related differences in the antioxidant defense...

Keywords: antioxidant capacity, coronary heart disease, gender differences, pericardial fluid, valvular heart disease

08/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Significance of small dense low-density lipoproteins as coronary risk factor in diabetic and non-diabetic Korean populations

Small dense low-density lipoproteins (LDLs) have been associated with coronary heart disease (CHD) and type 2 diabetes in previous studies...

Keywords: coronary heart disease, coronary risk factor, low-density lipoprotein (LDL) particle size, small dense low-density lipoprotein, type 2 diabetes mellitus

04/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
HDL and clinical and biochemical correlates in Italian non-smoker women

High-density lipoprotein (HDL)-cholesterol levels, inversely related to the risk of myocardial infarction, are determined by genetic and environmental factors...

Keywords: apolipoprotein A-I, coronary heart disease, estrogens, high-density lipoprotein, hypoalphalipoproteinemia

12/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease

P-selectin and its ligand, PSGL-1, are cell adhesion molecules that facilitate interaction of platelets, leukocytes and endothelial cells...

Keywords: allele-specific PCR, coronary heart disease, exon re-sequencing, hypercholesterolemia, single nucleotide polymorphisms

09/2004 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality

The endothelium plays a crucial role in the maintenance of vascular tone and structure by releasing the endothelium-derived vasoactive mediator, nitric oxide (NO)...

Keywords: coronary heart disease, endothelium, nitric oxide, Prognosis, risk factors

10/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Association study between fibronectin and coronary heart disease

Fibronectin is a known chemoattractant for several cell types that play a role in the wound healing process, including fibroblasts, endothelial cells and macrophages...

Keywords: atherosclerosis, coronary heart disease, fibronectin, gene polymorphism, plasma fibronectin

01/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Serum calcium and phosphorus associate with the occurrence and severity of angiographically documented coronary heart disease, possibly through correlation with atherogenic (apo)lipoproteins

The associations of serum calcium and phosphorus concentrations as well as other cardiovascular risk factors were investigated in relation to the existence and severity of coronary heart disease (CHD) in 260 clinically stable, angiographically defined CHD patients aged 40–70 years...

Keywords: apolipoprotein B, calcium, cholesterol, coronary heart disease, lipoprotein(a), phosphorus

01/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Apolipoprotein B gene 3?VNTR polymorphism: association with plasma lipids and coronary heart disease in Han Chinese

Background: Studies that considered polymorphisms within the apolipoprotein B (APOB) gene as risk factors for coronary heart disease (CHD) have reported conflicting results.

Methods: The phenotypic effects of the 3?VNTR polymorphism of the APOB gene on the susceptibility to CHD were investigated in 120 unrelated healthy individuals and 137 CHD patients...

Keywords: apolipoprotein B, Chinese, coronary heart disease, genotype, Polymorphism

10/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Lack of association between ?2B-adrenergic receptor polymorphism and risk of restenosis following coronary angioplasty and stent implantation – preliminary report

Background: A genetic association/prospective follow-up study was conducted to investigate whether genetic variation of the ?2B-adrenergic receptor gene was associated with the risk of restenosis in 96 Greek coronary artery disease patients undergoing coronary angioplasty and stent implantation.

Methods: For comparison of genotype frequency, a control group of 83 asymptomatic individuals was also studied...

Keywords: ?2B-adrenergic receptor, coronary heart disease, polymorphisms, restenosis

07/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Lipoprotein(a) Struktur, Epidemiologie und Funktion / Lipoprotein(a) structure, epidemiology and function

Zusammenfassung Jahrzehnte nach der Erstbeschreibung durch Berg 1963 ist Lipoprotein(a) (Lp(a)) als von den brigen kardiovaskulren Risikofaktoren unabhngiger Risikofaktor anerkannt...

Keywords: Atherosklerose, koronare Herzerkrankung, lipoprotein(a), Plasmalipoproteine, atherosclerosis, coronary heart disease, plasma lipoproteins

06/2007 | LaboratoriumsMedizin, Walter de Gruyter
Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics

This review focuses on (i) the current status of 1H NMR spectroscopy to quantify lipoprotein subclasses directly from serum or plasma, and (ii) the applications of 1H NMR metabonomics of serum in biomedicine...

Keywords: blood plasma and serum, coronary heart disease, data analysis, diagnostics, lipoprotein subclass, metabolomics, metabonomics, nuclear magnetic resonance spectroscopy, quantification, Risk assessment

01/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Association between plasma thiols and immune activation marker neopterin in stable coronary heart disease

Background: Studies have associated elevated plasma levels of the thiols homocysteine and cysteine with an increased risk of atherosclerosis...

Keywords: coronary heart disease, cysteine, gender difference, homocysteine, neopterin

05/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Apolipoprotein E polymorphism – a risk factor for metabolic syndrome

Background: Metabolic syndrome is closely related to several disturbances in lipid and lipoprotein metabolism...

Keywords: apolipoprotein E genotypes, coronary heart disease, dyslipidemia, metabolic syndrome, obesity

09/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study

Background: The aim of this pilot study was to evaluate the relationship between interleukin-6 promoter –174G/C (IL-6 –174G/C) polymorphism and insulin resistance (IR) in obese patients with coronary heart disease (CHD).

Methods: Twenty obese male patients with CHD were selected from a larger database of patients (n=606)...

Keywords: adiposity, coronary heart disease, genotype, high-density lipoprotein cholesterol, insulin resistance, Interleukin-6

09/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter