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Items for "connective tissue diseases"

Diagnostic accuracy of the FIDIS multiplex fluorescent microsphere immunodetection system for anti-extractable nuclear antigen (ENA) antibodies in connective tissue diseases

Background: Anti-extractable nuclear antigen antibodies (ENA) are markers of connective tissue diseases (CTDs).

Methods: We compared FIDIS reagents in the multiplex fluorescent microsphere immunodetection system to INNO-LIA and immunodiffusion for 174 antinuclear antibody-positive patients, 102 with well-defined CTDs and 72 disease controls.

Results: No significant differences were found in sensitivity or specificity between FIDIS and immunodiffusion, or between FIDIS and INNO-LIA for all anti-ENA in all CTD patients; nor were any differences found for individual anti-ENAs within distinct CTDs...

Keywords: anti-extractable nuclear antigen antibodies, antinuclear antibodies, autoimmunity, connective tissue diseases, immunoassays, Luminex, multiplex

04/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter
Labordiagnostik von Kollagenosen unter besonderer Berücksichtigung neurologischer Manifestationen / Labaratory diagnosis of connective tissue diseases with a focus on neurological manifestations

Zusammenfassung

Kollagenosen sind systemische Autoimmunerkrankungen. Die Diagnose erfolgt nach klinischen Klassifikationskriterien unter Berücksichtigung laborchemischer Parameter...

Keywords: ANA, antinukleäre Antikörper, Kollagenosen, Liquor, Peripheres Nervensystem, PNS, Serologie, Zentralnervensystem, ZNS, antinuclear antibodies, central nervous system, cerebrospinal fluid, CNS, connective tissue diseases, immunoserology, peripheral nervous system

10/2006 | LaboratoriumsMedizin, Walter de Gruyter