Items for "Coagulation"

Sorption of europium(III) on polymeric silica in perchlorate media

Sorption of europium, Eu(III) with polymeric silicic acid has been studied under varying experimental conditions such as pH, ionic strength (I), concentration of silicic acid and of Eu(III), the presence of carbonate ions, and aging time...

Keywords: Europium, Sorption, Silica, Polymerization, Coagulation

Inhibition of plasmatic coagulation: What is new?

The major goal in the development of new anticoagulant drugs is a more effective action with less adverse effects...

Keywords: Koagulation, Antikoagulanzien

Anticoagulant and anti-platelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, and acetylsalicylic acid

The pharmacokinetics, pharmacodynamics and safety of the direct factor Xa inhibitor, otamixaban, with and without concomitant acetylsalicylic acid (ASA) were investigated in healthy volunteers...

Keywords: Acetylsalicylic acid, Coagulation, factor Xa, pharmacokinetics, pharmacodynamics, o

Serum osteoprotegerin in young survivors of myocardial infarction

Osteoprotegerin (OPG) is a member of the tumour necrosis factor superfamily and is involved in the regulation of bone metabolism and vascular calcification...

Keywords: osteoprotegerin, homocysteine, Coagulation, thrombin generation, myocardial infarction

Chronological expression of PAR isoforms in acute liver injury and its amelioration by PAR2 blockade in a rat model of sepsis

The liver can be injured and its functions altered by activation of the coagulation and inflammatory processes in sepsis...

Keywords: Coagulation, endotoxin, inflammation, liver injury, protease-activated receptor (PAR)

Potent arterial antithrombotic effect of direct factor-Xa inhibition with ZK-807834 administered to coronary artery disease patients

It was the objective of this study to evaluate the anti-thrombotic potency of direct factor-Xa inhibition with ZK-807834 in stable coronary patients, using an ex-vivo model of arterial thrombus formation...

Keywords: Coagulation, Coronary disease, myocardial infarction, thrombosis, platelets

Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis: FnBPA is sufficient to activate human endothelial cells

Surface molecules of Staphylococcus aureus are involved in the colonization of vascular endothelium which is a crucial primary event in the pathogenesis of infective endocarditis (IE)...

Keywords: Staphylococcus aureus, endocarditis, Coagulation, fibronectin binding protein A, endothelium, activation

Insularinase A, a prothrombin activator from Bothrops insularis venom, is a metalloprotease derived from a gene encoding protease and disintegrin domains

The first low-molecular-mass metalloprotease presenting prothrombin activating activity was purified from Bothrops insularis venom and named insularinase A...

Keywords: Bothrops insularis, Coagulation, endothelial cell, metalloprotease, prothrombin activator, snake venom

Direct Simulation and Mass Flow Stochastic Algorithms to Solve a Sintering-Coagulation Equation

In this paper we introduce an efficient stochastic method to solve the time evolution of a bivariate population balance equation which has been developed for modelling nano-particle dynamics...

Keywords: Particle Size Distribution, Monte Carlo methods, Stochastic Processes, Sintering, Coagulation, mass flow

Coagulation-fibrinolysis is more enhanced in twin than in singleton pregnancies

Aims: To examine whether coagulation-fibrinolysis in late pregnancy in women with twin pregnancies is more pronounced than in women with singleton pregnancies.

Patients and methods: The plasma levels of D-dimer, fibrinogen/fibrin degradation products (FDP), and fibrinogen, the platelet count, and the antithrombin activity were assessed from 3 weeks before delivery until postpartum day 7 in 48 women (24 singleton and 24 twin pregnancies) without preeclampsia who underwent cesarean sections.

Results: Women with singleton or twin pregnancies gave birth at 37.3±1.2 weeks or 35.2±1.4 weeks, respectively...

Keywords: Antithrombin activity, Coagulation, D-dimer, fibrinolysis, twin

Hypochlorous acid is a potent inactivator of human plasminogen at concentrations secreted by activated granulocytes

Background: Myeloperoxidase (MPO) neutrophils have been considered an important pathophysiological factor in oxidative stress...

Keywords: atherosclerosis, Coagulation, myeloperoxidase, oxidative stress, Plasmin, thiols, thrombosis

Premature labor: a state of platelet activation?

Objective: This study was undertaken to determine whether premature labor is associated with changes in the maternal plasma concentration of soluble CD40 ligand (sCD40L), a marker of platelet activation.

Methods: A cross-sectional study included patients in the following groups: 1) non-pregnant (n=21); 2) normal pregnancy (n=71); 3) normal pregnancy at term with (n=67) and without labor (n=88); 4) preterm labor (PTL) with intact membranes (n=136) that was divided into the following sub-groups: 4a) PTL who delivered at term (n=49); 4b) PTL without intra-amniotic infection and/or inflammation (IAI) who delivered preterm (n=54); and 4c) PTL with IAI who delivered preterm (n=33)...

Keywords: Coagulation, inflammation, labor, prematurity, Platelet, thrombin, sCD40L