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Items for "Clinical studies"

Simple and safe exclusion of pulmonary embolism in outpatients using quantitative D-dimer and Wells' simplified decision rule

A safe and effective management strategy is pivotal in excluding pulmonary embolism (PE). The combination of Wells' simplified dichotomous clinical decision rule and D-dimer test is non-invasive and could be highly efficient, though its safety has not been widely studied...

Keywords: Clinical studies, pulmonary embolism, diagnosis management, D-dimer, clinical decision rule

01/2007 | Thrombosis and Haemostasis, Schattauer

The pharmacology of selective inhibition of COX-2

Selective inhibitors of cyclooxygenase (COX)-2 were developed to improve the safety of anti-inflammatory therapy in patients at elevated risk for gastrointestinal complications which are thought to be caused primarily by depression of COX-1 derived mucosal prostanoids...

Keywords: Clinical studies, atherothrombosis, atherosclerosis, inflammation, inflammatory mediators

10/2006 | Thrombosis and Haemostasis, Schattauer

Does a coxib-associated thrombotic risk limit the clinical use of the compounds as analgesic, antiinflammatory drugs? Arguments against

The issue of the risk-benefit assessment of cyclooxygenase-2 (COX-2) inhibitors, as compared to traditional non-steroidal anti-inflammatory drugs (tNSAIDs), is far from being resolved...