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Items for "chondroitin sulfate"

Pathophysiology and diagnostic value of urinary trypsin inhibitors

Inflammation is an important indicator of tissue injury. In the acute form, there is usually accumulation of fluids and plasma components in the affected tissues...

Keywords: antiprotease, autoimmune disease, bikunin, C-reactive protein, chondroitin sulfate, elastase, infection, inflammation, inter-?-inhibitor, pro-enzyme, proteolytic enzyme, protease-activated receptor, serine protease, urinary trypsin inhibitor

01/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Alterations in serum glycosaminoglycan profiles in Graves' patients

Background: Qualitative and quantitative analyses of glycosaminoglycans (GAGs) in serum obtained from Graves' disease (GD) patients without extrathyroidal complications were carried out to provide a clearer understanding of the role of these macromolecules in the disease pathogenesis.

Methods: GAGs were isolated from serum of 17 GD patients before treatment and after attainment of the euthyroid state, as well as from 20 healthy individuals...

Keywords: chondroitin sulfate, dermatan sulfate, Glycosaminoglycans, heparan sulfate/heparin

05/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Fine characterization of mitral valve glycosaminoglycans and their modification with degenerative disease

Background: The levels and fine structure of complex polysaccharides, glycosaminoglycans (GAGs), were determined in segments of the posterior mitral valve leaflet (MVL) taken from 15 patients affected by mitral regurgitation and degenerative disease and were compared with segments from 15 multiorgan donors.

Methods: MVL GAGs were analyzed by agarose gel electrophoresis, and by HPLC and fluorophore-assisted carbohydrate electrophoresis to evaluate disaccharide patterns after treatment with chondroitinase ABC.

Results: GAGs from the control group were composed of approximately 37% hyaluronic acid and 63% chondroitin sulfate/dermatan sulfate with a charge density of approximately 0.61...

Keywords: chondroitin sulfate, degenerative disease, Glycosaminoglycans, Hyaluronic acid, mitral valve

03/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Age-related changes of plasma glycosaminoglycans

Background: This study was undertaken to reveal how the physiological ageing process influences plasma glycosaminoglycans (GAGs) content and composition.

Methods: GAGs isolated from plasma samples obtained from 105 healthy subjects were quantified using a hexuronic acid assay and subjected to electrophoretic fractionation.

Results: We found that total GAGs decreased gradually with advancing age...

Keywords: ageing process, chondroitin sulfate, dermatan sulfate, extracellular matrix, heparin sulfate/heparin, plasma glycosaminoglycans