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Items for "chemoprevention"

Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells

Active inflammatory leukocytes are a major endogenous source of reactive oxygen and nitrogen oxide species (RONS)...

Keywords: chemoprevention, co-culture, macrophage, mutagenesis, nitric oxide, phytochemicals, superoxide

04/2006 | Biological Chemistry, Walter de Gruyter
Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells

Resveratrol is a polyphenolic chemopreventive agent that has been shown to influence cellular redox reactions...

Keywords: A549 cells, antioxidant capacity, cell cycle arrest, chemoprevention, glutathione peroxidase, selenoprotein

02/2007 | Biological Chemistry, Walter de Gruyter
A common CYP1B1 polymorphism is associated with 2-OHE1/16-OHE1 urinary estrone ratio

Cytochrome P450 (CYP) is a multigene family of enzymes involved in important life functions; some of these genes are inducible and are implicated in the oxidative metabolic activation and detoxification of many endogenous and exogenous compounds. CYP1B1 codes for an enzyme that catalyses the production of a 2- and 4-hydroxyl group in estrone and estradiol, while CYP1A1 catalyzes the 2-hydroxylation of estradiol in endometrium...

Keywords: chemoprevention, epidemiology, estrogen metabolism, transitional study

07/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter