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Items for "biomarker"

The l-arginine nitric oxide pathway: avenue for a multiple-level approach to assess vascular function

Endothelial dysfunction is an early stage of atherosclerosis and has been attributed to impaired nitric oxide (NO) bioactivity and enhanced formation of oxygen-derived free radicals...

Keywords: biomarker, endothelial dysfunction, endothelium, nitrite, NOS

10/2006 | Biological Chemistry, Walter de Gruyter

Within-subject variation of plasma resistin levels over a 1-year period

Background: Resistin, a recently discovered hormone, is purportedly involved in metabolic and inflammatory processes in humans and may thus be an important marker to assess disease risk in large-scale epidemiological studies.

Methods: We assessed the reliability of human resistin levels in 63 men and 51 women aged 35–67 years with repeated measurements of resistin over a period of 1 year...

Keywords: biomarker, inflammation, obesity, reliability, risk factor

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Protein profiling as a diagnostic tool in clinical chemistry: a review

Serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) appears to be an important diagnostic tool for a whole range of diseases...

Keywords: biomarker, decision tree, diagnostic value, ovarian cancer, post-analytical conditions, pre-analytical conditions, prostate cancer, protein profiling, proteomics, surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

12/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Combining markers of nephrotoxicity and hepatotoxicity for improved monitoring and detection of chronic alcohol abuse

Background: Most of the commonly used markers of chronic alcohol abuse reflect alcohol hepatotoxicity; however, such abuse is deleterious to the kidneys as well...

Keywords: ?-N-acetylhexosaminidase, biomarker, ?-glutamyltransferase, sensitivity, serum enzyme, specificity, urinary enzyme

12/2006 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

How to comprehensively analyse proteins and how this influences nutritional research

Proteomics, the comprehensive analysis of a protein complement in a cell, tissue or biological fluid at a given time, is a key platform within the “omic” technologies that also encompass genomics (gene analysis), transcriptomics (gene expression analysis) and metabolomics (metabolite profiling)...

Keywords: biomarker, health, Mass spectrometry, nutrition, proteomics

03/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Asymmetrisches Dimethylarginin (ADMA): ein neuer Marker zur Abschtzung des kardiovaskulren Risikos / Asymmetric dimethyl arginine (ADMA): a new marker for evaluating cardiovascular risk

Zusammenfassung Asymmetrisches Dimethylarginin (ADMA) ist eine endogen produzierte Aminosure, die alle drei Isoformen der Stickoxid-Synthase inhibiert...

Keywords: Asymmetrisches Dimethylarginin (ADMA), Atherosklerose, biomarker, endotheliale Dysfunktion, kardiovaskulres Risiko, Stickstoffmonoxid, atherosclerosis, aymmetric dimethyl arginine (ADMA), cardiovascular risk, coronary artery disease, endothelial dysfunction, nitric oxide

06/2007 | LaboratoriumsMedizin, Walter de Gruyter

Variability in longitudinal cerebrospinal fluid tau and phosphorylated tau measurements

Background: The influence of assay variation and duration of storage on changes in cerebrospinal fluid (CSF) levels of tau and phosphorylated (P)-tau with time was evaluated in 112 patients with various neurological disorders.

Methods: These patients (aged 66±9 years, 52% male), referred to our memory clinic, underwent two spinal taps (mean interval 19 months) and the baseline samples were assayed twice in a sandwich enzyme-linked immunosorbent assay (ELISA): once after the first spinal tap (A1) and once in a separately stored aliquot (A2) simultaneous with the follow-up sample (B).

Results: Coefficients of variances (CVs) of tau and P-tau levels determined in repeated spinal taps (?B–A2) measured in one assay (10.9% and 7.6%) were lower (p<0.01) than the CVs observed in two different (?B–A1) assays (16.5% and 11.7%)...

Keywords: biomarker, cerebrospinal fluid, phosphorylated (P)-tau, tau

09/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Quantification of vascular endothelial growth factor, interleukin-8, and basic fibroblast growth factor in plasma of cancer patients and healthy volunteers – comparison of ELISA and microsphere-based multiplexed immunoassay

Background: Vascular endothelial growth factor (VEGF), interleukin-8 (IL-8) and basic fibroblast growth factor (basic FGF) are angiogenic growth factors which may be useful as biomarkers in drug development, where they could give early information on the antiangiogenic activity of novel anticancer compounds.

Methods: We compared two commercially available assays, enzyme linked immunosorbent assay (ELISA) and a multiplexed bead-based immunoassay (xMAP), for the quantification of these factors in plasma samples from more than 100 cancer patients and healthy individuals.

Results: For VEGF and IL-8, but not for basic FGF, xMAP was more sensitive than the respective ELISA...

Keywords: Angiogenesis, biomarker, Cancer, growth factor, immunoassay

09/2008 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Biomarker bei Sepsis und Entzündung / Biomarkers in Sepsis and Inflammation

Zusammenfassung Schwere systemische Entzündungen wie die Sepsis und der septische Schock stellen die häufigste Todesursache auf der Intensivstation dar...

Keywords: biomarker, Cholesterin, Entzündung, IL-6, PCT, sepsis, Zytokine, cholesterol, cytokines, inflammation

12/2007 | LaboratoriumsMedizin, Walter de Gruyter

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Items for "biomarker"