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Items for "big endothelin-1"

Effects of nitric oxide and prostacyclin on hemodynamic response by big endothelin-1 in near term fetal sheep

Aims: To measure plasma concentrations of endothelin (ET)-1, NO metabolites (nitrate/nitrite; NOx) and 6-keto PGF1? (PGF1?) in maternal and fetal sheep blood, and to evaluate the effects of big ET-1 on hemodynamic response, blood gases and NO and 6-keto PGF1? production in near term fetal sheep.

Methods: Hemodynamic parameters were measured during infusion of big ET-1 into the carotid vein in chronically catheterized fetal sheep on day 125 of gestation...

Keywords: big endothelin-1, fetus, hypotension, 6-keto PGF1?), nitric oxide, sheep

11/2004 | Journal of Perinatal Medicine, Walter de Gruyter