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atherosclerosis
Items for "atherosclerosis"
Immunization of LDL receptor-deficient mice with & 2 -glycoprotein 1 or human serum albumin induces a more inflammatory phenotype in atherosclerotic plaques
Antiphospholipid antibodies are a risk factor for venous and arterial thrombosis and may contribute to the development of atherosclerosis...
Keywords: Antiphospholipid antibodies, atherosclerosis, β2-glycoprotein 1, immunization, statins
01/2007 | Thrombosis and Haemostasis, SchattauerThe role of platelets for the pathophysiology of acute coronary syndromes
Cardiovascular diseases, especially ischaemic heart disease, are actually the most frequent causes of death in the Western world and represent a central challenge for modern research and medicine...
Keywords: Akutes Koronarsyndrom, Atherosklerose, Thrombozyten, Myokardinfarkt
01/2006 | Hämostaseologie, SchattauerRole of the vascular wall in the pathophysiology of the acute coronary syndrome
The endothelium is of important significance in the development of the acute coronary syndrome. As an endo-/paracrine organ, the endothelium plays a key role in the regulation of the vascular homeostasis...
Keywords: Akutes Koronarsyndrom, Endotheldysfunktion, Stickstoffmonoxid, Atherosklerose
01/2006 | Hämostaseologie, SchattauerEffective Prevention of Carotid Artery Atherosclerosis by Following this Motto for Healthy Habits: Give Up One, Reduce Two, and Increase Three
OBJECTIVES : Lifestyle has a major influence on the development and progression of atherosclerosis. Our motto for healthy habits is give up one, reduce two, and increase three...
Keywords: atherosclerosis, lifestyle, carotid artery, ultrasonic
01/2005 | Methods of Information in Medicine, SchattauerNew Methods for Time-resolved Fluorescence Spectroscopy Data Analysis Based on the Laguerre Expansion Technique Applications in Tissue Diagnosis
OBJECTIVES: A new deconvolution method for the analysis of time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) data is introduced and applied for tissue diagnosis...
Keywords: Time-resolved fluorescence spectroscopy, Laguerre deconvolution, atherosclerosis
01/2007 | Methods of Information in Medicine, SchattauerEndothelial dysfunction and systemic inflammation in persons with echolucent carotid plaques
Echolucent carotid plaques are associated with high risk for future ischemic cerebrovascular events independent of the degree of stenosis...
Keywords: atherosclerosis, ultrasound / diagnosis, von Willebrand factor, plasminogen activators, Cerebrovascular disease
07/2006 | Thrombosis and Haemostasis, SchattauerThe pharmacology of selective inhibition of COX-2
Selective inhibitors of cyclooxygenase (COX)-2 were developed to improve the safety of anti-inflammatory therapy in patients at elevated risk for gastrointestinal complications which are thought to be caused primarily by depression of COX-1 derived mucosal prostanoids...
Keywords: Clinical studies, atherothrombosis, atherosclerosis, inflammation, inflammatory mediators
10/2006 | Thrombosis and Haemostasis, SchattauerCOX-2 inhibitors and cardiovascular risk. Inferences based on biology and clinical studies
Even though non-steroidal anti-inflammatory drugs (NSAIDs) have been widely used for a long time, the search continues for anti-inflammatory drugs with few side-effects...
Keywords: atherosclerosis, thrombosis, inflammation, hypercoagulability, coronary syndrome
10/2006 | Thrombosis and Haemostasis, SchattauerGenetic variations of the endothelial nitric oxide synthase gene are related to increased levels of C-reactive protein and macrophage-colony stimulating-factor in patients with coronary artery disease
It was the objective of this study to investigate the relation between nitric oxide synthase (NOS3) gene polymorphisms, vascular inflammation, endothelial function, and atherosclerosis...
Keywords: NO synthase gene polymorphisms, inflammation, atherosclerosis, vascular function
10/2006 | Thrombosis and Haemostasis, SchattauerPlatelet-induced growth of human fibroblasts is associated with an increased expression of 5-lipoxygenase
Proliferation of fibroblasts is vital for adequate wound healing but is probably also involved in different hyperproliferative disorders such as atherosclerosis and cancer...
Keywords: Fibroblasts, platelets, proliferation, 5-lipoxygenase, atherosclerosis
11/2006 | Thrombosis and Haemostasis, SchattauerNo difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease
Aspirin reduces several pro-inflammatory markers in patients with coronary heart disease (CHD), while limited data exists with clopidogrel...
Keywords: antiplatelet agents, inflammation, atherosclerosis, randomized trial
11/2006 | Thrombosis and Haemostasis, SchattauerAssessment of genetic risk for myocardial infarction
Although lifestyle and environmental factors influence the prevalence of myocardial infarction, genetic epidemiological studies have suggested that several genetic variants increase the risk for this condition...
Keywords: genetics, Polymorphism, myocardial infarction, coronary heart disease, atherosclerosis
08/2006 | Thrombosis and Haemostasis, SchattauerThe F11 receptor (F11R/JAM-A) in atherothrombosis: Overexpression of F11R in atherosclerotic plaques
F11R is the gene name for an adhesion protein, called the F11-receptor, aka JAM-A, which under normal physiological conditions is expressed constitutively on the surface of platelets and localized within tight junctions of endothelial cells (EC)...
Keywords: F11R, F11 receptor, F11R/JAM-A, inflammatory thrombosis, atherosclerosis, atherothrombosis
00/0000 | Thrombosis and Haemostasis, SchattauerFibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: The Rotterdam Study
Fibrin network structure has been correlated with coronary disease. Fibrinogen and (FGG and FGA) gene haplotypes (chromosome 4q28) may be associated with fibrin network structure, and thereby with rigidity of the fibrin clot and sensitivity of the fibrin clot to the fibrinolytic system...
Keywords: Coronary disease, atherosclerosis, epidemiology, genetics, fibrinogen
00/0000 | Thrombosis and Haemostasis, SchattaueruPAR uPA PAI-1 interactions and signaling: A vascular biologists view
The urokinase-type plasminogen activator (uPA), its inhibitor PAI-1 and its cellular receptor (uPAR), play a pivotal role in pericellular proteolysis...
Keywords: Urokinase / receptor, plasminogen activator inhibitors, Angiogenesis and inhibitors, atherosclerosis, restenosis
03/2007 | Thrombosis and Haemostasis, SchattauerRemodeling of carotid arteries is associated with increased expression of thrombomodulin in a mouse transverse aortic constriction model
Thrombomodulin (TM) is an endothelial glycoprotein that functions as a thrombin cofactor in the activation of protein C...
Keywords: arterial remodeling, atherosclerosis, thrombomodulin
04/2007 | Thrombosis and Haemostasis, SchattauerOxidative modification of low-density lipoprotein: lipid peroxidation by myeloperoxidase in the presence of nitrite
Oxidative modification of low-density lipoprotein (LDL) is a pivotal process in early atherogenesis and can be brought about by myeloperoxidase (MPO), which is capable of reacting with nitrite, a NO metabolite...
Keywords: antioxidant, atherosclerosis, cocoa, epicatechin, flavonoids, LDL oxidation, procyanidins
09/2004 | Biological Chemistry, Walter de GruyterHigh-sensitivity C-reactive protein concentration in patients with myocardial infarction-environmental factors, and polymorphisms in interleukin-10 and CD14 genes
Keywords: atherosclerosis, CD14, environmental factors, genetic polymorphisms, interleukin-10, myocardial infarction
07/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterInter-individual variation of inflammatory markers of cardiovascular risks and diseases
Cardiovascular diseases are a real public health problem and have multifactorial origin...
Keywords: atherosclerosis, environmental factors, intermediate phenotypes of inflammation, polymorphisms
07/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterThe significance of serum ?-glutamyltransferase in cardiovascular diseases
Since early after the introduction of serum ?-glutamyltransferase (GGT) in clinical practice as a reliable and widely employed laboratory test, epidemiological and prospective studies have repeatedly shown that this activity possesses a prognostic value for morbidity and mortality...
Keywords: atherosclerosis, glutathione, myocardial infarction, serum ?-glutamyltransferase, Stroke
10/2004 | Clinical Chemical Laboratory Medicine, Walter de GruyterAnti-N -homocysteinylated protein autoantibodies and cardiovascular disease
Metabolic conversion of homocysteine (Hcy) to a chemically reactive metabolite, Hcy-thiolactone, catalyzed by methionyl-tRNA synthetase is the first step in a pathway that is suggested to contribute to Hcy toxicity in humans...
Keywords: atherosclerosis, homocysteine-thiolactone, N-homocysteine-protein autoantibodies
10/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterConjugated linoleic acid suppresses the secretion of atherogenic lipoproteins from human HepG2 liver cells
Studies in healthy humans have shown that consumption of conjugated linoleic acid (CLA) significantly reduced very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) blood concentrations...
Keywords: apolipoprotein B100 (apoB100), atherosclerosis, cholesterol, conjugated linoleic acid, HepG2 liver cells, lipoprotein
03/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterAssociation study between fibronectin and coronary heart disease
Fibronectin is a known chemoattractant for several cell types that play a role in the wound healing process, including fibroblasts, endothelial cells and macrophages...
Keywords: atherosclerosis, coronary heart disease, fibronectin, gene polymorphism, plasma fibronectin
01/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterInhibition of the ubiquitin-proteasome system: a new avenue for atherosclerosis
Keywords: Aspirin, atherosclerosis, hypercholesterolemia, ubiquitin-proteasome system
10/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterInitiation and progression of atherosclerosis – enzymatic or oxidative modification of low-density lipoprotein?
Atherosclerosis is widely regarded as a chronic inflammatory disease that develops as a consequence of entrapment of low-density lipoprotein (LDL) in the arterial intima...
Keywords: atherosclerosis, enzymatically modified low-density lipoprotein (E-LDL), lipoproteins, macrophage, oxidized LDL (OxLDL)
12/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterNitration of human plasminogen by RAW 264.7 macrophages reduces streptokinase-induced plasmin activity
Despite many years of study, clinical trials of new drugs to prevent thrombosis have often been disappointing...
Keywords: atherosclerosis, diabetes, fibrinolysis, nitrosative stress, peroxynitrite, phagocytes
02/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterAnalytical performance and clinical efficacy for cardiovascular risk estimation of an Olympus immunoturbidimetric high-sensitivity C-reactive protein assay
Increased C-reactive protein (CRP) concentration within the reference interval (<10.0 mg/L) is a strong predictor of cardiovascular disease (CVD) in apparently healthy adults...
Keywords: atherosclerosis, cardiovascular disease, high-sensitivity C-reactive protein, hsCRP, immunoturbidimetry, Olympus
02/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterAssociation of angiotensin II type 1 receptor gene polymorphism with carotid atherosclerosis
Keywords: angiotensin II type 1 receptor, atherosclerosis, carotid artery, essential hypertension, gene polymorphism
03/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterC-Reactive protein and neopterin levels in healthy non-obese adults
Keywords: atherosclerosis, Body mass index, high-sensitivity C-reactive protein, inflammation, neopterin, waist-to-hip ratio
03/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterEvaluation of cardiovascular risk factors and related clinical markers in healthy young Japanese adults
Keywords: atherosclerosis, cardio-ankle vascular index, carotid intima-media thickness, folate, homocysteine, young adults
02/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterEmerging role of cathepsin S in obesity and its associated diseases
Obesity is thought to be a major determinant in the development of cardiovascular diseases, but the mechanisms whereby enlarged adipose tissue affects vascular function remain poorly defined...
Keywords: atherosclerosis, cathepsin S, obesity
03/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterOxidative stress evaluated using an automated method for hydroperoxide estimation in patients with coronary artery disease
Keywords: atherosclerosis, coronary artery disease, diabetes, hydroperoxides, oxidative stress, risk factors
03/2007 | Clinical Chemical Laboratory Medicine, Walter de GruyterHypoadiponectinemia is associated with symptomatic atherosclerotic peripheral arterial disease
There is growing evidence that adiponectin, an adipocytokine with anti-inflammatory and antiathero-genic properties, is involved in the development of atherosclerosis...
Keywords: adiponectin, atherosclerosis, peripheral vascular disease, risk factors
07/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterInflammatorische Biomarker und Atherosklerose/Inflammatory biomarkers and atherosclerosis
Keywords: Atherosklerose, immun-mediierte Entzündung, inflammatorische Biomarker, atherosclerosis, immune-mediated inflammation, inflammatory biomarkers
08/2004 | LaboratoriumsMedizin, Walter de GruyterLipoprotein(a) Struktur, Epidemiologie und Funktion / Lipoprotein(a) structure, epidemiology and function
Zusammenfassung Jahrzehnte nach der Erstbeschreibung durch Berg 1963 ist Lipoprotein(a) (Lp(a)) als von den brigen kardiovaskulren Risikofaktoren unabhngiger Risikofaktor anerkannt...
Keywords: Atherosklerose, koronare Herzerkrankung, lipoprotein(a), Plasmalipoproteine, atherosclerosis, coronary heart disease, plasma lipoproteins
06/2007 | LaboratoriumsMedizin, Walter de GruyterAsymmetrisches Dimethylarginin (ADMA): ein neuer Marker zur Abschtzung des kardiovaskulren Risikos / Asymmetric dimethyl arginine (ADMA): a new marker for evaluating cardiovascular risk
Zusammenfassung Asymmetrisches Dimethylarginin (ADMA) ist eine endogen produzierte Aminosure, die alle drei Isoformen der Stickoxid-Synthase inhibiert...
Keywords: Asymmetrisches Dimethylarginin (ADMA), Atherosklerose, biomarker, endotheliale Dysfunktion, kardiovaskulres Risiko, Stickstoffmonoxid, atherosclerosis, aymmetric dimethyl arginine (ADMA), cardiovascular risk, coronary artery disease, endothelial dysfunction, nitric oxide
06/2007 | LaboratoriumsMedizin, Walter de Gruyter