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Items for "Aptamer"

A potent anti-coagulant RNA aptamer inhibits blood coagulation by specifically blocking the extrinsic clotting pathway

A potent antidote-controlled aptamer, as an anticoagulant, has reportedly overcome the complications of acute bleeding by the administration of available anticoagulants...

Keywords: Aptamer, blood coagulation, extrinsic and intrinsic pathway, inhibition, RNA

05/2006 | Thrombosis and Haemostasis, Schattauer
Anti-innexin 2 aptamers specifically inhibit the heterologous interaction of the innexin 2 and innexin 3 carboxyl-termini in vitro

We recently demonstrated that heteromerization of innexins 2 and 3 from Drosophila melanogaster (Dm) is crucial for epithelial organization and polarity of the embryonic epidermis...

Keywords: Aptamer, Drosophila, gap junctions, innexin 2, innexin 3, in vitro selection

06/2007 | Biological Chemistry, Walter de Gruyter
Engineering high-speed allosteric hammerhead ribozymes

Full-length hammerhead ribozymes were subjected to in vitro selection to identify variants that are allosterically regulated by theophylline in the presence of a physiologically relevant concentration of Mg2+...

Keywords: Aptamer, riboswitch, RNA folding, RNA switch, self-cleavage, theophylline

01/2007 | Biological Chemistry, Walter de Gruyter