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Apoptosis
Items for "Apoptosis"
Plasminogen activator inhibitor-1 impairs plasminogen activation-mediated vascular smooth muscle cell apoptosis
The role of plasminogen activator inhibitor-1 (PAI-1) in vascular smooth muscle cell (VSMC) apoptosis mediated by plasminogen activation was studied with the use of aorticVSMC derived from mice with deficiency of PAI-1 (PAI-1 -/- ), tissue-type (t-PA -/- ) or urokinase-type (u-PA -/- ) plasminogen activator or from wildtype (WT) mice with corresponding genetic background...
Keywords: Apoptosis, proteolysis / pericellular, plasminogen activators, plasminogen activator inhibitors, plasminogen (-fragments)
11/2006 | Thrombosis and Haemostasis, SchattauerFormation of tissue factor-factor VIIa-factor Xa complex prevents apoptosis in human breast cancer cells
Tissue factor (TF) is a transmembrane glycoprotein that initiates blood coagulation when complexed with factor VIIa (FVIIa)...
Keywords: Apoptosis, breast cancer, factor VIIa, factor Xa, Tissue factor
08/2006 | Thrombosis and Haemostasis, SchattauerExpression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer
Apoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported...
Keywords: Apoptosis, BCL2L12, colon cancer
09/2004 | Biological Chemistry, Walter de GruyterAn apoptotic inducer, aralin, is a novel type II ribosome-inactivating protein from Aralia elata
We recently found that aralin, a novel cytotoxic protein consisting of two subunits, from
Keywords: Apoptosis, aralin, cytotoxic protein, lectin, ribosome-inactivating protein (RIP), RNA N-glycosidase
09/2004 | Biological Chemistry, Walter de GruyterCeramides induce programmed cell death in Arabidopsis cells in a calcium-dependent manner
While the role of C2-ceramide in the induction of programmed cell death (PCD) in animal systems has been well documented, little is known of its role in plant cells...
Keywords: Apoptosis, calcium signalling, reactive oxygen species
02/2005 | Biological Chemistry, Walter de GruyterQuercetin metabolism in vital and apoptotic human leukaemia cells
The metabolism of the flavonol quercetin in human leukaemia (HL-60) cells was investigated...
Keywords: Apoptosis, flavonol fluorescence, HL-60 cells, quercetin metabolism
03/2005 | Biological Chemistry, Walter de GruyterThe snake venom metalloproteases berythractivase and jararhagin activate endothelial cells
PIII snake venom metalloproteases (SVMPs) are metalloproteases structurally related to ADAMs (a disintegrin and metalloprotease human family of proteins)...
Keywords: Apoptosis, berythractivase, Coagulation, endothelial cell, fibrinolysis, jararhagin, prothrombin activator, snake venom metalloproteases (SVMP)
04/2005 | Biological Chemistry, Walter de GruyterhDLG/SAP97, a member of the MAGUK protein family, is a novel caspase target during cell-cell detachment in apoptosis
Cell-cell detachment is one of the hallmarks of apoptosis. To date, several transmembrane and plaque proteins from tight and adherent junctions have been characterised as caspase targets during apoptosis...
Keywords: Apoptosis, caspase substrate, cell-cell junctions, human discs large protein (hDLG), membrane-associated guanylate kinase (MAGUK)
07/2005 | Biological Chemistry, Walter de GruyterRegulatory effects of the mitochondrial energetic status on mitochondrial p66Shc
p66Shc promotes apoptosis and controls the intracellular redox balance...
Keywords: Apoptosis, mitochondria, reactive oxygen species
10/2006 | Biological Chemistry, Walter de GruyterMitochondrial morphology and distribution in mammalian cells
It is now appreciated that mitochondria form tubular networks that adapt to the requirements of the cell by undergoing changes in their shape through fission and fusion...
Keywords: Apoptosis, cytoskeleton, Fission, fusion, mitochondria
12/2006 | Biological Chemistry, Walter de GruyterTopotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells
The
Keywords: Apoptosis, BAX, BCL2L12, caspase, FAS, leukemia, methotrexate, topotecan
12/2006 | Biological Chemistry, Walter de GruyterThe tissue kallikrein-kinin system protects against cardiovascular and renal diseases and ischemic stroke independently of blood pressure reduction
Tissue kallikrein (hK1) cleaves low-molecular-weight kininogen to produce kinin peptide, which binds to kinin receptors and triggers a wide spectrum of biological effects...
Keywords: Angiogenesis, Apoptosis, brain, heart, hypertension, kinin B2 receptor, oxidative stress, tissue kallikrein
06/2006 | Biological Chemistry, Walter de GruyterCysteine cathepsins and caspases in silicosis
Silicosis is an occupational pneumoconiosis caused by inhalation of crystalline silica...
Keywords: Apoptosis, bronchoalveolar lavage, fibrosis, inflammation, protease, protease inhibitor
07/2006 | Biological Chemistry, Walter de GruyterTreatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS
We studied alterations in the mRNA expression levels of
Keywords: Apoptosis, BAX, breast cancer, BCL2L12, caspase, etoposide, FAS, taxol
08/2006 | Biological Chemistry, Walter de GruyterEvidence supporting the hypothesis that one of the main functions of the aryl hydrocarbon receptor is mediation of cell stress responses
We have previously proposed that one of the major consequences of activation of the aryl hydrocarbon receptor (AhR) by 2,3,7,8-tetrachlorodibenzo-
Keywords: AhR, Apoptosis, cholesterol, IL-8, inflammation, TCDD
09/2006 | Biological Chemistry, Walter de GruyterBinding of aflatoxins to the 20S proteasome: effects on enzyme functionality and implications for oxidative stress and apoptosis
Aflatoxins (AF) are contaminants of improperly stored foods; they are potent genotoxic and carcinogenic compounds, exerting their effects through damage to DNA...
Keywords: aflatoxin, Apoptosis, HepG2, oxidative stress, proteasome, proteolytic activity
01/2007 | Biological Chemistry, Walter de GruyterApoptotic DNA fragmentation is not related to the phosphorylation state of histone H1
Changes in chromatin structure, histone phosphorylation and cleavage of DNA into nucleosome-size fragments are characteristic features of apoptosis...
Keywords: Apoptosis, caspase-activated DNase (CAD), chromatin, DNA fragmentation, histone phosphorylation, human tumor cell lines
02/2007 | Biological Chemistry, Walter de GruyterIncreased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-β1-signaling and upregulation of cathepsin B
The TGF-β signaling pathways are implicated in cancer. Cysteine cathepsins can contribute to the carcinogenic potential of tumor cells...
Keywords: Apoptosis, Cancer, cysteine, Migration, promoter, protease
06/2007 | Biological Chemistry, Walter de GruyterAdrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria
Mitochondrial cytochrome P450 systems are an indispensable component of mammalian steroid biosynthesis; they catalyze regio- and stereo-specific steroid hydroxylations and consist of three protein entities: adrenodoxin reductase (AdR), adrenodoxin (Adx), and a mitochondrial cytochrome P450 enzyme, e.g., CYP11A1 (P450 side chain cleavage, P450scc)...
Keywords: adrenodoxin, Apoptosis, CYP11A1, cytochrome P450, electron transfer chain, mitochondria, reactive oxygen species, steroid hydroxylation
05/2005 | Biological Chemistry, Walter de GruyterEffect of bleomycin and cisplatin on the expression profile of SRA1 , a novel member of pre-mRNA splicing factors, in HL-60 human promyelocytic leukemia cells
Recently, a new member of the human SR (Ser/Arg-rich) superfamily of pre-mRNA splicing factors,
Keywords: anticancer drugs, Apoptosis, DNA laddering, MTT, RT-PCR, splicing
01/2007 | Biological Chemistry, Walter de GruyterThe molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function
Selenoproteins have been recognized as modulators of brain function and signaling. Phospholipid hydroperoxide glutathione peroxidase (GPx4/PHGPx) is a unique member of selenium-dependent glutathione peroxidases in mammals with a pivotal role for brain development and function...
Keywords: Apoptosis, embryogenesis, excitotoxicity, glial cells, oxidative stress, phosphoinositides, selenium
01/2007 | Biological Chemistry, Walter de GruyterCellular localization of MAGI-1 caspase cleavage products and their role in apoptosis
MAGI-1 is a
Keywords: Apoptosis, caspase, cell junctions, MAGI-1, MAGUK
01/2007 | Biological Chemistry, Walter de Gruyter?-Tocopherol as an antiretroviral therapy supplement for HIV-1-infected patients for increased lymphocyte viability
The aim of our study was to evaluate the benefits of supplementation with 800 mg/day of ?-tocopherol with regard to cellular viability in HIV-1 seropositive patients undergoing anti-retroviral therapy...
Keywords: antiretroviral therapy, Apoptosis, cellular viability, HIV, oxidative stress, ?-tocpherol
04/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter“Coelionomics”: towards understanding the molecular pathology of coeliac disease
Coeliac disease (CD) is an inflammatory disorder of the small intestine characterised by a permanent intolerance to gluten-derived peptides...
Keywords: Apoptosis, coeliac disease, matrix metalloproteinases, oxidative stress, proliferation and differentiation
07/2005 | Clinical Chemical Laboratory Medicine, Walter de GruyterIncrease in and clearance of cell-free plasma DNA in hemodialysis quantified by real-time PCR
Keywords: Apoptosis, cell-free plasma DNA, circulating DNA, Dialysis membrane, Hemodialysis, real-time PCR, renal insufficiency
12/2006 | Clinical Chemical Laboratory Medicine, Walter de GruyterFetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathways
Inflammatory cytokines are involved in both preterm labor and preterm premature of the membranes pathways; however, the interaction between TNF-? and its receptors may dictate the clinical outcome of pregnancy.
Keywords: cytokines, preterm labor, prematurity, PROM, MMPs, Apoptosis
09/2004 | Journal of Perinatal Medicine, Walter de GruyterIs cervical dilatation during parturition at term associated with apoptosis?
Keywords: Apoptosis, cervical dilatation, cervix, parturition, proliferation
03/2005 | Journal of Perinatal Medicine, Walter de GruyterIs cervical dilatation during parturition at term associated with apoptosis?
Keywords: Apoptosis, cervical dilatation, cervix, parturition, proliferation
03/2004 | Journal of Perinatal Medicine, Walter de Gruyter