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Items for "apolipoprotein E"

The composition, structural properties and binding of very-low-density and low-density lipoproteins to the LDL receptor in normo- and hypertriglyceridemia: relation to the apolipoprotein E phenotype

The composition, apolipoprotein structure and lipoprotein binding to the LDL receptor were studied for very-low-density (VLDL) and low-density lipoprotein (LDL) particles isolated from subjects with apoE phenotype E3/3 (E3), E2/2 or E2/3 (E2+) and E3/4 or E4/4 (E4+) and a wide range of plasma triglyceride (TG) contents...

Keywords: apolipoprotein C-III, apolipoprotein E, low-density lipoprotein (LDL), low-density lipoprotein receptor, very-low-density lipoprotein (VLDL)

05/2005 | Biological Chemistry, Walter de Gruyter

Impact of genetic polymorphisms on the risk of lipid disorders in patients on anti-HIV therapy

Active anti-HIV therapy can induce hypertriglyceridemia, low high-density lipoprotein (HDL) and insulin resistance, eventually accompanied by clinical lipodystrophy, associated loss of subcutaneous adipose tissue and an increase in abdominal adiposity...

Keywords: antiretroviral therapy, apolipoprotein A-V, apolipoprotein C-III, apolipoprotein E, dyslipidemia, HIV, lipodystrophy, pharmacogenomics, protease inhibitors, tumor necrosis factor-? (TNF?)

07/2007 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Apolipoprotein E haplotyping by denaturing high-performance liquid chromatography

The apolipoprotein E ( APOE) gene in humans contains two single-base polymorphisms in exon 4, which result in three common alleles, conventionally named ?2, ?3 and ?4...

Keywords: apolipoprotein E, denaturing HPLC, haplotyping, single-nucleotide polymorphism

05/2005 | Clinical Chemical Laboratory Medicine, Walter de Gruyter

Associations of apolipoprotein E exon 4 and lipoprotein lipase S447X polymorphisms with acute ischemic stroke and myocardial infarction

Background: Because apolipoprotein E (apoE) and lipopoprotein lipase (LPL) polymorphisms interact with each other and with other factors to affect lipid metabolism, we sought to determine their separate and combined effects in association with ischemic vascular disease.

Methods: We performed a case-control study of 816 subjects: 246 acute ischemic stroke patients, 234 acute myocardial infarction patients, and 336 controls...

Keywords: apolipoprotein E, ischemic, lipoprotein lipase, Polymorphism, smoking