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Items for "Antithrombin"

Antithrombin reduces endotoxin-induced hypotension by enhancing pulmonary sensory neuron activation in rats

We recently demonstrated that activation of the pulmonary sensory neurons plays a critical role in prevention of endotoxininduced shock by releasing calcitonin gene-related peptide (CGRP) in rats...

Keywords: Antithrombin, Capsaicin-sensitive sensory neurons, calcitonin gene-related peptide, septic shock, protein kinase A

06/2006 | Thrombosis and Haemostasis, Schattauer

Anti-thrombotic effect of bivalirudin compared with eptifibatide and unfractionated heparin in diabetic patients. An ex vivo human study

Patients with diabetes who undergo percutaneous coronary intervention (PCI) are at high risk for thrombotic complications following the procedure...

Keywords: Antithrombin, diabetes/metabolic disorders, platelet pharmacology, antiplatelet drugs, direct antithrombin agents

03/2006 | Thrombosis and Haemostasis, Schattauer

Biodistribution of covalent antithrombin-heparin complexes

We have developed a covalent antithrombin-heparin (ATH) complex with advantages compared to non-covalent antithrombin:heparin (AT:H) mixtures...

Keywords: Antithrombin, heparin, pharmacodynamics

04/2006 | Thrombosis and Haemostasis, Schattauer

Antithrombin reduces reperfusion-induced liver injury in mice by enhancing sensory neuron activation

We recently demonstrated that antithrombin (AT) reduces ischemia/reperfusion (I/R)-induced liver injury in rats by increasing hepatic tissue levels of calcitonin gene-related peptide (CGRP), a neuropeptide released from the sensory nerve endings...

Keywords: Antithrombin, Capsaicin-sensitive sensory neurons, calcitonin gene-related peptide, liver injury, protein kinase A

05/2006 | Thrombosis and Haemostasis, Schattauer

Heparin modulation of human plasma kallikrein on different substrates and inhibitors

The interplay of different proteases and glycosaminoglycans is able to modulate the activity of the enzymes and to affect their structures...

Keywords: Antithrombin, C1-inhibitor, Factor XII, Glycosaminoglycans, plasminogen, synthetic substrates

08/2006 | Biological Chemistry, Walter de Gruyter