Items for "anti-extractable nuclear antigen antibodies"

Diagnostic accuracy of the FIDIS multiplex fluorescent microsphere immunodetection system for anti-extractable nuclear antigen (ENA) antibodies in connective tissue diseases

Background: Anti-extractable nuclear antigen antibodies (ENA) are markers of connective tissue diseases (CTDs).

Methods: We compared FIDIS reagents in the multiplex fluorescent microsphere immunodetection system to INNO-LIA and immunodiffusion for 174 antinuclear antibody-positive patients, 102 with well-defined CTDs and 72 disease controls.

Results: No significant differences were found in sensitivity or specificity between FIDIS and immunodiffusion, or between FIDIS and INNO-LIA for all anti-ENA in all CTD patients; nor were any differences found for individual anti-ENAs within distinct CTDs...

Keywords: anti-extractable nuclear antigen antibodies, antinuclear antibodies, autoimmunity, connective tissue diseases, immunoassays, Luminex, multiplex